Role of gp120 in dendritic cell dysfunction in HIV infection
Role of gp120 in dendritic cell dysfunction in HIV infection
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DOI：
10.1189/jlb.0306135
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发表时间：
2006-11-01
影响因子：
5.5
通讯作者：
Gessani, Sandra
中科院分区：
文献类型：
--
作者：
Chougnet, Claire;Gessani, Sandra
只有有限部分的循环病毒粒子具有明显的感染性;因此，暴露于灭活病毒可能模拟体内发生的最常见类型的CD 4-HIV相互作用。最近的几项研究强调了这些非感染性病毒在HIV感染者免疫功能缺陷中的关键作用，特别是在树突状细胞（DC）功能失调中。在这篇综述中，我们讨论了DC和HIV gp 120或灭活病毒之间的相互作用如何通过直接（直接接触）或间接机制（作为原发性CD 4（+）T细胞失调的结果，随后是缺陷的CD 4-DC相互作用）导致DC功能受损。重要的是，这些功能受损的DC不能向T细胞提供最佳信号，但似乎有利于调节性T细胞的出现。因此，gp 120介导的DC功能损伤可能在HIV疾病的发病机制中发挥重要作用。J.利瓦克80：994-1000;2006.
Only a limited fraction of circulating virions are demonstrably infectious; therefore, exposure to inactivated viruses may mimic the most frequent type of CD4-HIV interactions that occur in vivo. Several studies have recently underscored the crucial role that those noninfectious viruses could play in defective immune function in HIV-infected individuals and in particular, in the dysregulation of dendritic cell (DC) function. In this review, we discuss how interactions between DC and HIV gp120 or inactivated virus, which harbor intact surface gp120, lead to impaired DC function through direct (direct contact) or indirect mechanisms (as a consequence of primary CD4(+) T cell dysregulation, followed by defective CD4-DC interactions). It is important that these functionally impaired DCs fail to give optimal signal to T cells but appear to favor the emergence of regulatory T cells. gp120-mediated impairment of DC function could therefore play an important role in the pathogenesis of HIV disease. J. Leukoc. Biol. 80: 994-1000;2006.