NEURITIC PLAQUES AND VESSELS OF VISUAL-CORTEX IN AGING AND ALZHEIMERS DEMENTIA
NEURITIC PLAQUES AND VESSELS OF VISUAL-CORTEX IN AGING AND ALZHEIMERS DEMENTIA
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DOI：
10.1016/0197-4580(90)90001-g
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发表时间：
1990-07-01
影响因子：
4.2
通讯作者：
BALL, MJ
中科院分区：
文献类型：
--
作者：
BELL, MA;BALL, MJ
用碱性磷酸酶染色的人死后视觉皮层厚切片测量了正常衰老和阿尔茨海默氏痴呆症患者微血管尺寸的变化。正常老年人和痴呆老年人的毛细血管密度下降程度相同。在两组中选择用于分析的领域包括所有皮质层，并在可能的情况下，包括淀粉样蛋白核心的神经斑块。痴呆组在这些选定区域的平均斑块密度略高，但不显著。在两组中，斑块在毛细血管密度最高（II-IV）的视层中更丰富，但正常老年人的斑块与血管之间的距离比痴呆患者更近。斑块分布不同；正常老年人斑块集中于IV层；在痴呆患者中，它们更均匀地分布在纹层中。痴呆患者斑块核较大。淀粉样血管病在痴呆组更为常见和广泛；淀粉样蛋白斑块与受累血管关系不密切。斑块分布在患有和不患有淀粉样血管病的阿尔茨海默病患者中有所不同；斑块密度在无血管病变的患者中最大。阿尔茨海默氏痴呆症与微血管功能的下降无关。血管化良好的椎板中的斑块浓度提示某些血源性病原体的致病作用。斑块分布的差异表明，在正常和痴呆衰老中，或者在有和没有淀粉样血管病的病例中，药物的作用是不同的。
Changes in microvascular dimensions occurring with normal aging and Alzheimer''s dementia were measured in thick sections of postmortem human visual cortex stained for alkaline phosphatase. Capillary density was decreased to the same degree in both normal aged and demented aged subjects. The fields selected for analysis in both groups included all cortical laminae and, where possible, amyloid-cored neuritic plaques. The mean density of such plaques in these selected fields was slightly but not significantly higher in the demented group. In both groups plaques were more plentiful in visual laminae with the highest capillary densities (II-IV), but plaques and vessels were closer to each other in the normal aged than in the demented. Plaque distributions differed; in the normal aged, plaques concentrated in lamina IV; in the demented they were more evenly spread throughout the laminae. Plaque cores were larger in the demented. Amyloid angiopathy was more common and more extensive in the demented group; amyloid-cored plaques were not closely associated with affected vessels. Plaque distributions in Alzheimer subjects with and without amyloid angiopathy differed; plaque density was greatest in those without angiopathy. Alzheimer''s dementia was not associated with any decline in microvascularity. Plaque concentration in well vascularized laminae suggests a pathogenetic role for some blood-borne agent. Differences in plaque distributions imply that the role or the agent differs in normal and demented aging, or perhaps between cases with and without amyloid angiopathy.