BIOASSAY FOR EVALUATING THE POTENCY OF AIRBORNE SENSORY IRRITANTS AND PREDICTING ACCEPTABLE LEVELS OF EXPOSURE IN MAN
BIOASSAY FOR EVALUATING THE POTENCY OF AIRBORNE SENSORY IRRITANTS AND PREDICTING ACCEPTABLE LEVELS OF EXPOSURE IN MAN
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DOI：
10.1016/0015-6264(81)90513-7
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
ALARIE, Y
中科院分区：
文献类型：
--
作者：
ALARIE, Y
使用动物（小鼠）生物测定来评估各种空气传播的感觉刺激物的效力。获得了每种化学物质的浓度-反应关系，并比较了这些感官刺激物的效力。尝试根据动物生物测定中获得的数据来预测人类的反应。我们发现这些化学物质的阈限值与根据每种化学物质的效力预测人类可接受的水平之间存在良好的相关性。
An animal (mouse) bioassay was used to evaluate the potency of a wide variety of airborne sensory irritants. Concentration-response relationships were obtained for each chemical and the potencies of these sensory irritants were compared. An attempt was made to predict from the data obtained in the animal bioassay what the response would be in humans. A good correlation was found between threshold limit values for these chemicals and the level that, on the basis of the potency of each chemical, would be predicted to be acceptable in humans.