Developmentally regulated gene from Leishmania encodes a putative membrane transport protein.
Developmentally regulated gene from Leishmania encodes a putative membrane transport protein.
复制标题
来自利什曼原虫的发育调控基因编码一种假定的膜转运蛋白。
DOI：
10.1073/pnas.86.20.7682
复制
发表时间：
1989
影响因子：
11.1
通讯作者：
Landfear,SM
中科院分区：
文献类型：
--
作者：
Cairns,BR;Collard,MW;Landfear,SM
We have cloned a developmentally regulated gene from the parasitic protozoan Leishmania enrietti. The mRNA from this gene accumulates to a much higher level in the promastigote stage of the parasite life cycle that lives in the gut of the insect vector than in the amastigote stage of the parasite that lives inside the macrophages of the mammalian host. The predicted protein encoded by this gene is homologous to the human erythrocyte glucose transporter and to several sugar-transport proteins from Escherichia coli. These structural similarities strongly suggest that the cloned gene encodes a membrane transport protein that is developmentally induced when the parasite enters its insect vector. Regulated membrane transporters may be required for the parasite to adapt to the environment of the insect gut.
