Epicatechin ingested via cocoa products reduces blood pressure in humans: a nonlinear regression model with a Bayesian approach
Epicatechin ingested via cocoa products reduces blood pressure in humans: a nonlinear regression model with a Bayesian approach
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DOI：
10.3945/ajcn.111.029330
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发表时间：
2012-06-01
影响因子：
7.1
通讯作者：
Helfrich, Hans-Peter
中科院分区：
文献类型：
--
作者：
Ellinger, Sabine;Reusch, Andreas;Helfrich, Hans-Peter
背景资料：基于经典随机效应模型的随机对照试验（RCT）的四项荟萃分析表明，可可消费可以降低收缩压（SBP）和舒张压（DBP）。因为表儿茶素被认为是治疗效果的原因，血压的变化应该取决于摄入表儿茶素的剂量，这可以解释研究之间的差异。目的：目的是量化通过可可产品摄入表儿茶素对SBP和DBP变化的影响。设计：选择非线性荟萃回归模型来研究表儿茶素剂量对SBP和DBP变化的影响。采用马尔可夫链蒙特卡罗方法的贝叶斯方法被应用于一个适当的治疗nonlinear.Results：数据来自16个随机对照试验的SBP和15个随机对照试验的DBP。通过可可制品摄入表儿茶素的关闭影响收缩压和舒张压的变化。SBP和DBP降低的渐近限值分别估计为-4.6 mmHg（95% CI：-5.4，-3.9 mmHg）和-2.1 mmHg（95% CI：-2.7，-1.6 mmHg）。摄入25 mg表儿茶素/d导致平均降低-4.1 mm Hg（95% CI：-4.6，-3.6 mmHg），SBP和-2.0 mmHg（95% CI：-2.4，-1.5 mm Hg）。结论：通过食用可可制品降低血压取决于摄入的表儿茶素的剂量，这解释了经典荟萃分析中研究间的大部分差异。食用其他富含表儿茶素的食物也可以达到类似的效果。美国临床营养杂志2012;95：1365-77。
Background: Four meta-analyses of randomized controlled trials (RCTs) based on the classical random-effects model showed that cocoa consumption can reduce systolic blood pressure (SBP) and diastolic blood pressure (DBP). Because epicatechin is suggested to be responsible for the treatment effect, changes in blood pressure should depend on the dose of ingested epicatechin, which may explain the between-study differences.Objective: The objective was to quantify the effect of epicatechin ingested via cocoa products on changes in SBP and DBP.Design: A nonlinear meta-regression model was chosen to investigate the impact of the epicatechin dose on changes in SBP and DBP. A Bayesian approach using Markov chain Monte Carlo methods was applied for an appropriate treatment of the nonlinearity.Results: Data from 16 RCTs on SBP and 15 RCTs on DBP were included. The close of epicatechin ingested via cocoa products influenced the changes in SBP and DBP. The asymptotic limit for the reduction was estimated at -4.6 mm Hg (95% Cl: -5.4, -3.9 mm Hg) for SBP and at -2.1 mm Hg (95% Cl: -2.7, -1.6 mm Hg) for DBP. An intake of 25 mg epicatechin/d led to a mean reduction of -4.1 mm Hg (95% Cl: -4.6, -3.6 mm Hg) in SBP and of -2.0 mm Hg (95% Cl: -2.4, -1.5 mm Hg) in DBP.Conclusions: Blood pressure reduction by consumption of cocoa products depends on the dose of ingested epicatechin, which explains most of the between-study differences in classical meta-analyses. Similar effects may be achieved by consumption of other foods that are also rich in epicatechin. Am J Clin Nutr 2012;95:1365-77.