Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons
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DOI：
10.1073/pnas.0504099102
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发表时间：
2005-07-26
影响因子：
11.1
通讯作者：
Yew, AC
中科院分区：
文献类型：
--
作者：
Dougherty, DP;Wright, GA;Yew, AC
我们开发了 G 蛋白偶联信号通路的机械数学模型，该通路负责在青蛙嗅觉受体神经元中产生电流反应。该模型结合了配体-受体相互作用、涉及第二信使 cAMP 的细胞内转导事件、效应离子通道活性和钙介导的反馈步骤的描述。我们根据用多种气味浓度刺激的单细胞的吸移管电流记录对模型进行参数化。所提出的模型准确地预测了神经元对短暂和长时间的气味暴露的受体电流反应，并且能够产生在重复或持续刺激下观察到的适应。
We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.