Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.
Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.
复制标题
DOI：
10.1186/s13014-016-0742-3
复制
发表时间：
2017-01-05
期刊：
影响因子：
--
通讯作者：
Shirato H
中科院分区：
文献类型：
--
作者：
Katoh N;Soda I;Tamamura H;Takahashi S;Uchinami Y;Ishiyama H;Ota K;Inoue T;Onimaru R;Shibuya K;Hayakawa K;Shirato H
研究使用实时肿瘤跟踪放疗（RTRT）系统进行立体定向体部放疗（SBRT）治疗的I期和IIA期非小细胞肺癌（NSCLC）患者的临床结局。采用相同的临床报告格式，在四家机构中回顾性研究了采用RTRT治疗经组织学证实的外周定位I期和IIA期NSCLC的SBRT治疗模式。结果模式也以同样的方式进行了调查。从2000年9月至2012年4月，共确定了283例患者的286个肿瘤。中位年龄为78岁（52-90岁），肿瘤最大直径为9 - 65 mm，中位数为24 mm。使用线性二次模型计算的等中心生物学有效剂量（10）为66戈伊-126戈伊，中位数为106戈伊。中位随访期为28个月（范围0-127），整个组、IA期和IB + IIA期的总生存率在2年时分别为75%、79%和65%，在3年时分别为64%、70%和50%。在多变量分析中，女性是总生存率的有利预测因素。四个机构的临床结局之间没有差异。29例（10.2%）、9例（3.2%）、0例和0例患者发生2级、3级、4级和5级放射性肺炎。亚组分析显示，与从大体肿瘤体积（GTV）到计划靶体积（PTV）的边界≥ 10 mm相比，边界< 10 mm不会降低总生存率和局部控制率，同时降低放射性肺炎的风险。这项多机构回顾性研究表明，结果与最近SBRT的护理模式和结局模式分析一致。将需要进行前瞻性研究，以评估使用RTRT系统的SBRT，边缘从GTV到PTV <10 mm。本文的在线版本（doi：10.1186/s13014-016-0742-3）包含补充材料，可供授权用户使用。
To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner. From September 2000 to April 2012, 283 patients with 286 tumors were identified. The median age was 78 years (52–90) and the maximum tumor diameters were 9 to 65 mm with a median of 24 mm. The calculated biologically effective dose (10) at the isocenter using the linear-quadratic model was from 66 Gy to 126 Gy with a median of 106 Gy. With a median follow-up period of 28 months (range 0–127), the overall survival rate for the entire group, for stage IA, and for stage IB + IIA was 75%, 79%, and 65% at 2 years, and 64%, 70%, and 50% at 3 years, respectively. In the multivariate analysis, the favorable predictive factor was female for overall survival. There were no differences between the clinical outcomes at the four institutions. Grade 2, 3, 4, and 5 radiation pneumonitis was experienced by 29 (10.2%), 9 (3.2%), 0, and 0 patients. The subgroup analyses revealed that compared to margins from gross tumor volume (GTV) to planning target volume (PTV) ≥ 10 mm, margins < 10 mm did not worsen the overall survival and local control rates, while reducing the risk of radiation pneumonitis. This multi-institutional retrospective study showed that the results were consistent with the recent patterns-of-care and patterns-of-outcome analysis of SBRT. A prospective study will be required to evaluate SBRT using a RTRT system with margins from GTV to PTV < 10mm. The online version of this article (doi:10.1186/s13014-016-0742-3) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
5.7
作者：
Borst, Gerben R.;Ishikawa, Masayori;Sonke, Jan-Jakob
通讯作者：
Sonke, Jan-Jakob
DOI：
10.1016/j.ijrobp.2005.01.025
发表时间：
2005-09-01
影响因子：
7
作者：
Onimaru, R;Shirato, H;Miyasaka, K
通讯作者：
Miyasaka, K
影响因子：
51.1
作者：
Chang, Joe Y.;Senan, Suresh;Paul, Marinus A.;Mehran, Reza J.;Louie, Alexander V.;Balter, Peter;Groen, Harry J. M.;McRae, Stephen E.;Widder, Joachim;Feng, Lei;van den Borne, Ben E. E. M.;Munsell, Mark F.;Hurkmans, Coen;Berry, Donald A.;van Werkhoven, Erik;Kresl, John J.;Dingemans, Anne-Marie;Dawood, Omar;Haasbeek, Cornelis J. A.;Carpenter, Larry S.;De Jaeger, Katrien;Komaki, Ritsuko;Slotman, Ben J.;Smit, Egbert F.;Roth, Jack A.
通讯作者：
Roth, Jack A.
影响因子：
20.4
作者：
Guckenberger, Matthias;Allgaeuer, Michael;Andratschke, Nicolaus
通讯作者：
Andratschke, Nicolaus
影响因子：
20.4
作者：
Onishi, Hiroshi;Shirato, Hiroki;Araki, Tsutomu
通讯作者：
Araki, Tsutomu