ADENINE-ARABINOSIDE 5'-MONOPHOSPHATE TREATMENT OF CHRONIC TYPE-B HEPATITIS
ADENINE-ARABINOSIDE 5'-MONOPHOSPHATE TREATMENT OF CHRONIC TYPE-B HEPATITIS
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DOI：
10.1002/hep.1840020606
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发表时间：
1982-01-01
期刊：
影响因子：
13.5
通讯作者：
ISHAK, K
中科院分区：
文献类型：
--
作者：
HOOFNAGLE, JH;MINUK, GY;ISHAK, K
6例慢性B型肝炎患者用5′-单磷酸阿糖腺苷10 ~ 15 mg/kg/d，连用10天。所有患者的血清B型肝炎病毒DNA和DNA聚合酶均立即显著下降，6例患者中有5例在治疗结束时两种标志物均为阴性。1例患者在停止治疗时B肝炎病毒DNA和DNA聚合酶仍为阴性。该患者随后表现出疾病活动的临床、血清生化和组织学缓解，同时伴有B e肝炎抗原向抗体的血清转化。在其余5例患者中，血清B型肝炎病毒DNA和DNA聚合酶在治疗停止后不久恢复到治疗前的值，这些患者的临床、生化、血清学或组织学特征均无显著变化。治疗的副作用是轻微和短暂的。这些结果表明，在大多数慢性B型肝炎患者中，10天疗程的阿糖腺苷5′-单磷酸不足以诱导感染和疾病活动的永久性改善。
Six patients with chronic type B hepatitis were treated with adenine arabinoside 5′–monophosphate at a dosage of 10 to 15 mg per kg per day for 10 days. All demonstrated an immediate and marked decrease in serum hepatitis B virus DNA and DNA polymerase, and 5 of the 6 became negative for both markers by the end of the period of therapy. One patient remained negative for hepatitis B virus DNA and DNA polymerase when therapy was discontinued. This patient subsequently exhibited clinical, serum biochemical, and histological remission in disease activity concurrent with seroconversion from hepatitis B e antigen to antibody. In the remaining five patients, serum hepatitis B virus DNA and DNA polymerase returned to pretreatment values soon after therapy was stopped, and these patients demonstrated no significant changes in clinical, biochemical, serological, or histological features of the disease. Side effects of the therapy were mild and transient. These results suggest that a 10–day course of adenine arabinoside 5′–monophosphate is not adequate to induce permanent amelioration of infection and disease activity in the majority of patients with chronic type B hepatitis.