The cellular basis for volume changes in the rat cortex during puberty: White and gray matter
The cellular basis for volume changes in the rat cortex during puberty: White and gray matter
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DOI：
10.1196/annals.1308.058
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Markham, JA
中科院分区：
文献类型：
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作者：
Juraska, JM;Markham, JA
我们发现，大鼠大脑皮层在青春期的发育变化与人类皮质的发育变化相似。与人类一样，尽管轴突总数减少，但由于有髓鞘轴突数量增加，大鼠大脑白质在此期间增加。我们有初步证据表明雌激素会降低髓鞘形成率，从而导致成年大鼠出现性别差异。与人类皮质的另一个相似之处是皮质大小的非线性变化。我们发现，在某些皮质区域，雌性大鼠在青春期表现出皮质体积和神经元数量的减少，而切除卵巢可以阻止这些减少。大鼠皮层可以作为青少年人类体积变化背后的细胞变化的模型。
We have found that developmental changes through the adolescent period in the rat cerebral cortex provide parallels to those seen in the human cortex. Like humans, the rat cerebral white matter increases during this time due to increases in the number of axons that become myelinated even while the total number of axons decreases. We have preliminary evidence that estrogen decreases the rate of myelination, which results in a sex difference in adult rats. Another parallel to the human cortex is the nonlinear changes in the size of the cortex. We have found that in some cortical regions, female rats show decreases in cortical volume and number of neurons across the time of puberty, and removal of the ovaries stops these decreases. The rat cortex may serve as a model for the cellular changes underlying the volume changes seen in adolescent humans.