PrrC, a Sco homologue from Rhodobacter sphaeroides, possesses thiol-disulfide oxidoreductase activity
PrrC, a Sco homologue from Rhodobacter sphaeroides, possesses thiol-disulfide oxidoreductase activity
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DOI：
10.1016/j.febslet.2007.08.058
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发表时间：
2007-10-02
期刊：
影响因子：
3.5
通讯作者：
McEwan, Alastair G.
中科院分区：
文献类型：
--
作者：
Badrick, Alison C.;Hamilton, Amanda J.;McEwan, Alastair G.
PrrC是球形红细菌中的Sco同源物，其与PrrBA相关，PrrBA是一种双组分信号转导系统，其响应于氧张力的降低而诱导光合作用基因表达。虽然Sco蛋白已被证明与铜结合，但它们与硫氧还蛋白结构相关的观察结果表明它们可能具有硫醇-二硫化物氧化还原酶活性。我们的研究结果表明，PrrC还原Cu 2+为Cu+，并具有二硫键还原酶活性。这些结果表明，一些细菌的Sco蛋白可能具有不同于线粒体Sco蛋白的生化特性。(c)2007年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
PrrC is a Sco homologue in Rhodobacter sphaeroides that is associated with PrrBA, a two-component signal transduction system that induces photosynthesis gene expression in response to a decrease in oxygen tension. Although Sco proteins have been shown to bind copper the observation that they are structurally-related to thioredoxins suggested that they might possess thiol-disulfide oxidoreductase activity. Our results show that PrrC reduces Cu2+ to Cu+ and possesses disulfide reductase activity. These results indicate that some bacterial Sco proteins may have biochemical properties that are distinct from those of mitochondrial Sco proteins. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.