The TATA-Binding Protein as a Regulator of Cellular Transformation
The TATA-Binding Protein as a Regulator of Cellular Transformation
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DOI：
10.4161/cc.2.5.493
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发表时间：
2003-01-01
期刊：
影响因子：
4.3
通讯作者：
Johnson, Deborah L.
中科院分区：
文献类型：
--
作者：
Johnson, Sandra A. S.;Dubeau, Louis;Johnson, Deborah L.
TATA结合蛋白TBP被所有三种RNA聚合酶使用，因此对基因表达过程至关重要。TBP与几种蛋白质亚类结合，称为TATA结合蛋白相关因子（TAF）。这导致形成至少三种不同的复合物，SL1、TFIID和TFIIIB，其分别决定TBP是否在RNA聚合酶（pol）I、pol II或pol III转录中起作用。基因表达的调控主要集中在蛋白质上，这些蛋白质用于调节一般转录组分（如TBP）与启动子相互作用的效率。基础转录因子本身被调节并影响细胞内稳态的可能性尚未得到广泛考虑。然而，最近的研究表明，TBP确实是受调控的，其细胞浓度的调节对基因表达具有深远的，令人惊讶的选择性影响，可以介导细胞对生长刺激的正常增殖反应以及细胞的转化潜力。
The TATA-binding protein, TBP, is used by all three RNA polymerases and is therefore central to the process of gene expression. TBP associates with several subsets of proteins, called TATA-binding protein-associated factors (TAFs). This results in the formation of at least three distinct complexes, SL1, TFIID, and TFIIIB, which dictates whether TBP functions in RNA polymerase (pol) I, pol II, or pol III transcription, respectively. The regulation of gene expression has focused largely on proteins that serve to modulate the efficiency by which the general transcription components, such as TBP, interact with promoters. The possibility of a basal transcription factor, itself, being regulated, and influencing cellular homeostasis, has not been extensively considered. However, recent studies have indicated that TBP is indeed regulated, and that modulation of its cellular concentration has a profound, and surprisingly selective, impact on gene expression that can mediate the normal proliferative responses of cells to growth stimuli as well as the transformation potential of cells.