The prevalence of misidentification syndromes in neurodegenerative diseases
The prevalence of misidentification syndromes in neurodegenerative diseases
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DOI：
10.1097/wad.0b013e3181641341
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发表时间：
2008-04-01
影响因子：
2.1
通讯作者：
Kertesz, Andrew
中科院分区：
文献类型：
--
作者：
Harciarek, Michal;Kertesz, Andrew
虽然在阿尔茨海默病（AD）中经常描述错误识别综合征（MISs），但这些现象在不同神经退行性疾病中的患病率尚未得到系统研究。392名可能患有AD的个体，119名患有额颞叶痴呆（FTD-bv）的行为多样性的患者，101名患有原发性进行性失语的患者，24名患有语义性痴呆的受试者，18名患有皮质基底节变性的受试者，8名患有进行性核上性麻痹的患者，36名可能患有路易体痴呆（DLB）的个体，26例帕金森病（Parkinson disease，PD）患者作为研究对象。在与患者及其可靠照顾者进行半结构化访谈的基础上，15.8%的AD病例、16.6%的DLB患者和8.3%的语义性痴呆患者确定了MIS。MIS最常见的形式是卡普格拉妄想，通常伴有重叠的地方，幻影寄宿现象，或两者兼而有之。虽然MIS通常出现在疾病的后期，但它也可以在AD患者中令人惊讶地早期发生。FTD-bv、原发性进行性失语、皮质基底节变性/核上性麻痹或PD患者均未发生MIS。因此，我们的研究结果表明，MIS是AD和DLB的特征，并倾向于排除FTD/Pick复合物和PD。
Although misidentification syndromes (MISs) have been often described in Alzheimer disease (AD), the prevalence of these phenomena in different neurodegenerative diseases has not been systematically studied. Three hundred ninety-two individuals with probable AD, 119 patients with the behavioral variety of frontotemporal dementia (FTD-bv), 101 patients with primary progressive aphasia, 24 subjects with semantic dementia, 18 subjects with corticobasal degeneration, 8 patients with progressive supranuclear palsy, 36 individuals with probable Lewy body dementia (DLB), and 26 subjects with Parkinson disease (PD) were the participants of this study. On the basis of a semistructured interview with both patients and their reliable caregivers, MIS was identified in 15.8% of cases with AD, 16.6% of patients with DLB, and in 8.3% of individuals with semantic dementia. The most frequent form of MIS was Capgras delusions, often accompanied by reduplication of place, phantom boarder phenomenon, or both. Although MIS typically appears in later stages of the disease, it can also occur surprisingly early in patients with AD. None of the patients with FTD-bv, primary progressive aphasia, corticobasal degeneration/supranuclear palsy, or PD developed MIS. Thus, our findings suggest that MISs are characteristic of AD and DLB, and tend to exclude FTD/Pick complex and PD.