Fast voice-coil scanning optical-resolution photoacoustic microscopy.
Fast voice-coil scanning optical-resolution photoacoustic microscopy.
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DOI：
10.1364/ol.36.000139
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发表时间：
2011-01-15
期刊：
影响因子：
3.6
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Wang L;Maslov K;Yao J;Rao B;Wang LV
我们开发了一种具有光学分辨率实时成像能力的光声成像系统。该成像系统能够在9毫米范围内以20赫兹的频率扫描，在1毫米的扫描范围内最高可达40赫兹。在光学非散射介质中测量，聚焦的激光光束提供3.4μm的横向分辨率。微米大小的碳颗粒或全血在硅胶管中的流动，以及小鼠耳朵毛细血管中的单个红细胞(RBC)的流动也被实时成像，这表明有能力以微米级的分辨率成像体内高度动态的过程。
We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9-mm range, and up to 40 Hz over a 1-mm scanning range. A focused laser beam provides a lateral resolution of 3.4 μm as measured in an optically nonscattering medium. Flows of micron-sized carbon particles or whole blood in a silicone tube and individual red blood cells (RBCs) in mouse ear capillaries were also imaged in real time, which demonstrated the capability to image highly dynamic processes in vivo at a micron-scale resolution.