Glucoprivic treatments that induce anestrus, but do not affect food intake, increase FOS-like immunoreactivity in the area postrema and nucleus of the solitary tract in Syrian hamsters.
Glucoprivic treatments that induce anestrus, but do not affect food intake, increase FOS-like immunoreactivity in the area postrema and nucleus of the solitary tract in Syrian hamsters.
复制标题
诱导不发情但不影响食物摄入的 Glucoprivic 治疗会增加叙利亚仓鼠孤束后区和孤束核的 FOS 样免疫反应性。
DOI：
10.1016/0006-8993(95)00860-s
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发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Gabriel,JM
中科院分区：
文献类型：
--
作者：
Schneider,JE;Finnerty,BC;Swann,JM;Gabriel,JM
为了维持体内热量的平衡，动物会进行各种各样的生理和行为调整。例如，当细胞代谢燃料的可用性较低时，大多数动物会增加食物摄入量。大鼠的后脑区（AP）和邻近的相互神经支配的孤立束核（NTS）是控制食物摄入代谢的重要脑区。然而，在叙利亚仓鼠中，食物摄入量不受代谢燃料可用性减少的影响，如食物剥夺或代谢燃料的药理抑制剂。当代谢燃料的可用性较低时，仓鼠会做出其他调整来保存能量。高剂量的2-脱氧-d -葡萄糖（2DG）可以抑制发情周期，这是一种抑制细胞葡萄糖利用的药物，但棕榈酸甲酯（MP）一种抑制脂肪酸利用的药物不能抑制发情周期。最近的数据表明，AP/NTS对葡萄糖活化对发情周期的影响至关重要。AP/NTS病变可预防2dg诱导的癫痫发作。如果AP/NTS参与葡萄糖活化诱导的早衰，那么可以预测，通过测定AP/NTS的fos样免疫反应性（FOS-li），诱导早衰的葡萄糖活化治疗将改变AP/NTS的神经激活模式。我们检测了被剥夺食物或随意喂食的雌性，以及被2DG、MP或适当的载体处理的雌性的FOS-li。FOS-li仅在剥夺食物或2DG处理的仓鼠AP/NTS中增加，这两种处理诱导了停发但对食物摄取量没有影响。这些结果与发情周期的代谢控制涉及检测AP/NTS中代谢燃料可用性的减少的概念是一致的。
Animals make a wide variety of physiological and behavioral adjustments in order to maintain caloric homeostasis. For example, most animals increase food intake when the availability of cellular metabolic fuels is low. The area postrema (AP) and adjacent, reciprocally-innervated nucleus of the solitary tract (NTS) are important brain areas for metabolic control of food intake in rats. However, in Syrian hamsters, food intake is not affected by decreases in metabolic fuel availability such as those that occur with food deprivation or with pharmacological inhibitors of metabolic fuels. Hamsters make other adjustments that conserve energy when the availability of metabolic fuels is low. Estrous cycles are inhibited by treatment with a high dose of 2-deoxy- d-glucose (2DG), a drug that inhibits cellular glucose utilization, but not by treatment with methyl palmoxirate (MP) a drug that inhibits fatty acid utilization. Recent data suggest that the AP/NTS is critical for the effects of glucoprivation on estrous cycles. Lesions of the AP/NTS prevent 2DG-induced anestrus. If the AP/NTS is involved in anestrus induced by glucoprivation, it might be predicted that glucoprivic treatments that induce anestrus would change patterns of neural activation, as measured by FOS-like immunoreactivity (FOS-li), in the AP/NTS. We examined FOS-li in females that were either food deprived or fed ad libitum, and in females treated with 2DG, MP or the appropriate vehicle. FOS-li was increased in the AP/NTS only in hamsters food deprived or treated with 2DG, the two treatments that induce anestrus but have no effect on food intake. These results are consistent with the notion that metabolic control of estrous cycles involves detection of decreases in the availability of metabolic fuels in the AP/NTS.