Polynucleotides II : The X-ray diffraction patterns of solutions of the randomly coiled and helical forms of polyriboadenylic acid†
Polynucleotides II : The X-ray diffraction patterns of solutions of the randomly coiled and helical forms of polyriboadenylic acid†
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多核苷酸 II：随机卷曲和螺旋形式的聚核糖腺苷酸溶液的 X 射线衍射图†
DOI：
10.1016/s0022-2836(59)80039-5
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发表时间：
1959
期刊：
影响因子：
--
通讯作者：
J. R. Fresco
中科院分区：
文献类型：
--
作者：
J. R. Fresco
已经可以获得以尖锐粉末图形式的酸形式的聚核糖腺苷酸的稀溶液的广角X射线衍射照片。如此测量的间距表明溶液中的聚合物结构与作为纤维的固态聚合物结构之间的显著相似程度。因此，纤维可以用聚合物的酸形式来识别。这些意见被认为是在两个建议的模型的螺旋形式的聚核糖腺苷酸。它的结论是，他们是唯一兼容的模型，其中有腺嘌呤基团之间的氢键作为主要的凝聚力链相互作用的相对链。稀溶液的酸稳定的聚核糖腺苷酸（螺旋形式）的能力，以提供清晰的衍射图案作为证据，个别分子的行为作为微晶。
It has been possible to obtain wide-angle X-ray diffraction photographs of dilute solutions of the acid form of polyriboadenylic acid in the form of sharp powder diagrams. The spacings so measured indicate a marked degree of similarity between the structure of the polymer in solution and in the solid state as a fibre. Consequently, the fibre can be identified with the acid form of the polymer. These observations are considered in terms of the two proposed models of the helical form of polyriboadenylic acid. It is concluded that they are only compatible with the model which has hydrogen bonds between the adenine groups of opposite chains as major cohesive forces for chain interaction. The ability of dilute solutions of acid-stable polyriboadenylic acid (helical form) to give sharp diffraction patterns is taken as evidence that individual molecules behave as microcrystals.