Selenium Supplementation, Body Mass Composition, and Leptin Levels in Patients with Obesity on a Balanced Mildly Hypocaloric Diet: A Pilot Study
Selenium Supplementation, Body Mass Composition, and Leptin Levels in Patients with Obesity on a Balanced Mildly Hypocaloric Diet: A Pilot Study
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DOI：
10.1155/2020/4802739
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发表时间：
2020-05-28
影响因子：
2.8
通讯作者：
Mian, Caterina
中科院分区：
文献类型：
--
作者：
Cavedon, Elisabetta;Manso, Jacopo;Mian, Caterina
背景充足的硒（Se）水平对几种慢性疾病有保护作用，如肥胖症。本研究的目的是评估在选定的一组肥胖患者中补充硒的效果。方法.这项随机前瞻性研究包括37名年龄在18-65岁之间的超重/肥胖个体，他们采用轻微低热量饮食3个月。干预组接受240 μ g/天的L-硒代蛋氨酸治疗3个月;对照组接受安慰剂。在治疗开始和结束时测试临床和生化参数、身体成分测量和心理总体幸福指数（PGWBI）问卷。结果两组的比较显示，在干预组中，从基线到随访结束，身体成分发生了显著变化，包括体脂量减少。与安慰剂组不同，硒组的瘦体重和肌肉质量显着增加，瘦素水平显着下降3个月后的饮食。在随访结束时，给予Se的组在PGWBI上的得分高于那些没有的组。结论硒可加强膳食对超重和肥胖的作用。这项工作在ISRCTN登记研究中注册，研究ID为。
Background. Adequate levels of selenium (Se) have protective effects against several chronic diseases, such as obesity. The aim of this study was to assess the effect of Se supplementation in a selected group of patients with obesity. Methods. This randomized prospective study included 37 overweight/obese individuals aged 18-65 years, who adopted a slightly hypocaloric diet for 3 months. An intervention group received 240 mu g/day of L-selenomethionine for 3 months; a control group received a placebo. Clinical and biochemical parameters, body composition measurements, and the Psychological General Well-Being Index (PGWBI) questionnaire were tested at the beginning and end of the treatment. Results. A comparison of the two groups showed a significant change in body composition, involving a decrease in body fat mass, between the baseline and the end of the follow-up, in the intervention group. Unlike the placebo group, the group given Se had a significant increase in lean body and muscle mass and a significant decrease in leptin levels after 3 months on diet. At the end of the follow-up, the group given Se scored higher on the PGWBI than those who did not. Conclusion. Se could reinforce the effects of diet for overweight and obesity. This work was registered in the ISRCTN registry with study ID .