Within-subject variation of plasma resistin levels over a 1-year period
Within-subject variation of plasma resistin levels over a 1-year period
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DOI：
10.1515/cclm.2007.148
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发表时间：
2007-01-01
影响因子：
6.8
通讯作者：
Pischon, Tobias
中科院分区：
文献类型：
--
作者：
Weikert, Cornelia;Westphal, Sabine;Pischon, Tobias
背景资料：抵抗素，最近发现的激素，据称参与人类的代谢和炎症过程，因此可能是一个重要的标志，以评估疾病的风险，在大规模的流行病学study.Methods：我们评估的可靠性，在63名男性和51名女性，年龄在35 - 67岁，在一段时间内重复测量的resistin的人resistin水平的resistin 1年。使用Student配对t检验比较基线和1年后的血清肌酐浓度。组内相关系数（ICCs）计算方差analysis of variance. Results：有没有显着差异，在基线和1年后，两种性别合并或单独分析时，男性和女性之间的BLORN浓度。两种性别的ICC均为0.70（95% CI 0.59 - 0.78），男性为0.75（95% CI 0.62 - 0.84），女性为0.66（95% CI 0.47 - 0.79）。抵抗素水平没有显着相关的年龄，体重指数，腰臀比，性别，或空腹status.Conclusions：个人血液中的抵抗素浓度没有显着变化，在一段时间内的1年，但表现出高度的可靠性。我们的研究结果表明，在流行病学研究中，一个单一的BLORN测量可能是足够的风险评估。
Background: Resistin, a recently discovered hormone, is purportedly involved in metabolic and inflammatory processes in humans and may thus be an important marker to assess disease risk in large-scale epidemiological studies.Methods: We assessed the reliability of human resistin levels in 63 men and 51 women aged 35-67 years with repeated measurements of resistin over a period of 1 year. Student's paired t-test was used to compare resistin concentrations at baseline and 1 year later. Intraclass correlation coefficients (ICCs) were calculated by analysis of variance.Results: There was no significant difference between resistin concentrations at baseline and after 1 year for both sexes combined or when analyzed separately for men and women. The ICCs were 0.70 (95% Cl 0.59-0.78) for both sexes combined, 0.75 (95% Cl 0.62-0.84) for men, and 0.66 (95% Cl 0.47-0.79) for women. Resistin levels were not significantly related to age, body mass index, waist-to-hip ratio, sex, or fasting status.Conclusions: Individual blood resistin concentrations did not significantly change over a period of 1 year, but showed a high degree of reliability. Our findings suggest that a single resistin measurement may be sufficient for risk assessment in epidemiological studies.