The clinical use of allografts, demineralized bone matrices, synthetic bone graft substitutes and osteoinductive growth factors: a survey study.
The clinical use of allografts, demineralized bone matrices, synthetic bone graft substitutes and osteoinductive growth factors: a survey study.
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DOI：
10.1007/s11420-005-0111-5
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发表时间：
2005-09-01
期刊：
影响因子：
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通讯作者：
Seigerman, Daniel A
中科院分区：
文献类型：
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作者：
Bostrom, Mathias P G;Seigerman, Daniel A
新的骨移植选择和替代品的出现导致在确定骨科中需要骨移植的外科手术的最合适产品时存在很大的不确定性。同种异体移植物、脱矿骨基质、合成骨移植替代物和骨诱导生长因子都是可行的选择，但缺乏这些产品临床使用的数据报告。该通信报告了27个月期间在特殊外科医院使用骨移植产品的情况，并根据手术使用、安全性和成本提出了建议。大约一半（48.6%）的骨移植替代物在脊柱手术期间植入。关节置换术、创伤和足/手病例也都使用了大量的植骨产品（分别为20.1%、19.0%、12.1%）。注意到各骨科学科之间在植骨产品的使用方面存在相当大的差异。在关节置换术中使用的所有骨移植替代物中，14.4%为脱钙骨基质，而56.8%为同种异体移植物。脱矿骨基质移植物用于82%的创伤手术和89%的足/手病例。在我们的研究期接近结束时，注意到合成骨移植替代品的增加。
The emergence of new bone grafting options and alternatives has led to significant uncertainty when determining the most appropriate product for surgical procedures requiring bone graft in orthopedics. Allografts, demineralized bone matrices, synthetic bone graft substitutes, and osteoinductive growth factors are all viable options, yet there is a lack of data reporting clinical usage of these products. This correspondence reports on the use of bone grafting products at the Hospital for Special Surgery for a 27-month period and makes recommendations based on surgical usage, safety, and cost. Approximately half (48.6%) of all bone graft substitutes were implanted during spinal surgery. Arthroplasty, trauma, and foot/hand cases all used considerable amounts of bone grafting products as well (20.1%, 19.0%, 12.1%, respectively). Considerable differences were noticed in usage of bone grafting products among each orthopedic discipline. Of all bone graft substitutes used in arthroplasty, 14.4% were demineralized bone matrices, whereas 56.8% were allografts. Demineralized bone matrix grafts were used in 82% of trauma surgery and 89% of foot/hand cases. An increase in synthetic bone graft alternatives was noticed near the end of our investigation period.