Synthesis and characterization of an anti-caries and remineratizing fluorine-containing cationic polymer PHMB-F
Synthesis and characterization of an anti-caries and remineratizing fluorine-containing cationic polymer PHMB-F
复制标题
防龋再矿化含氟阳离子聚合物PHMB-F的合成与表征
DOI：
10.1039/d0bm01627f
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发表时间：
2021-03-21
影响因子：
6.6
通讯作者：
Li, X. D.
中科院分区：
文献类型：
--
作者：
Chen, Y. D.;Shu, C.;Li, X. D.
龋齿已成为一个重大的全球公共卫生问题。菌斑控制和初期釉质损伤的再矿化对于预防和控制龋病至关重要。聚六亚甲基双胍(PHMB)是一种阳离子两亲性抗菌剂，具有广谱抗菌性能和良好的生物安全性。氟化物可以延缓牙齿硬组织的脱矿和促进其再矿化。然而，它需要高浓度才能起到抗菌剂的作用。为了合成具有与氟化物相关的优点的PHMB，我们合成了一种含氟的阳离子聚合物PHMB-F。傅里叶变换红外光谱和固体核磁共振表征证实了PHMB-F的成功合成。抑菌试验表明，PHMB-F对变形链球菌的杀菌效果优于单独使用PHMB。此外，带正电荷的PHMB-F允许氟离子以负电位更接近牙釉质表面，这显著降低了维持平衡所需的坚硬牙齿组织附近微环境中的离子浓度。因此，牙釉质再矿化只需要低浓度的PHMB-F。
Dental caries have become a major global public health problem. Plaque control and remineralization of initial enamel lesions are paramount for the prevention and control of caries. Polyhexamethylene biguanide (PHMB) is a type of cationic amphipathic antibacterial agent with broad-spectrum antibacterial properties and good biological safety. Fluoride delays demineralization and promotes the remineralization of hard dental tissues. However, a high concentration is needed for it to function as an antibacterial agent. In order to create a PHMB with the benefits associated with fluoride, we synthesized a fluorine-containing cationic polymer, PHMB-F. Fourier transform-infrared spectroscopy and solid state nuclear magnetic resonance characterization confirmed the successful synthesis of PHMB-F. Antibacterial tests showed that PHMB-F had better antiseptic efficacy for Streptococcus mutans compared with just PHMB. Moreover, positively-charged PHMB-F allows fluoride ions to exist closer to the enamel surface with negative potential, which markedly lowers the ion concentrations in the microenvironment adjacent to hard dental tissues needed to maintain equilibrium. Thus, only low concentrations of PHMB-F are required for enamel remineralization.