LTP in the mouse nucleus accumbens is developmentally regulated.
LTP in the mouse nucleus accumbens is developmentally regulated.
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小鼠伏隔核中的 LTP 受到发育调节。
DOI：
10.1002/syn.10104
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Winder,DannyG
中科院分区：
文献类型：
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作者：
Schramm,NicoleL;Egli,RegulaE;Winder,DannyG
谷氨酸能传递在丘脑核（NAc）已被证明是重要的行为适应药物滥用的反应。NMDA受体依赖性长时程增强（LTP）的突触传递已被假设为许多持久的行为改变的基础。因此，我们研究了NAc核心的LTP，发现它是发育调节的。具体而言，在“青春期”（3周龄）小鼠的NAc中观察到破伤风诱发的NMDA受体依赖性LTP的频率高于成年（6-20周龄）小鼠。相比之下，cAMP依赖性的传输增强不受发育调节。去除细胞外Mg 2+恢复LTP在成人NAC核心，这表明发育调节的诱导过程，而不是维护机制。这些研究结果的背景下，引起的行为变化的药物滥用，这在青少年与成年啮齿动物和人类不同。Synapse 45：213-219，2002.© 2002 Wiley利斯公司
Glutamatergic transmission in the nucleus accumbens (NAc) has been shown to be important for behavioral adaptations in response to drugs of abuse. NMDA‐receptor dependent long‐term potentiation (LTP) of glutamatergic synaptic transmission has been hypothesized to underlie many lasting alterations in behavior. Thus, we examined LTP in NAc core and find that it is developmentally regulated. Specifically, tetanus‐evoked, NMDA receptor‐dependent LTP is observed in the NAc of “adolescent” (3‐week‐old) mice more frequently than in adult (6–20‐week‐old) mice. In contrast, cAMP‐dependent enhancement of transmission is not developmentally regulated. Removal of extracellular Mg2+restores LTP in adult NAc core, suggesting developmental regulation of induction processes rather than maintenance mechanisms. These findings are discussed in the context of behavioral changes elicited in response to drugs of abuse, which differ in adolescent vs. adult rodents and humans. Synapse 45:213–219, 2002. © 2002 Wiley‐Liss, Inc.