Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis.
Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis.
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DOI：
10.1155/2017/5190986
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Wu L
中科院分区：
文献类型：
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作者：
Li L;Liu H;Shi W;Liu H;Yang J;Xu D;Huang H;Wu L
骨关节炎（OA）是一种以关节软骨破坏、滑膜炎症和骨赘形成为特征的慢性退行性关节疾病。目前尚无有效的治疗方法。目前的药物治疗，如非甾体抗炎药（NSAIDs）和镇痛药，伴随可能的不良反应，可能改善OA症状。但它们并不能阻止骨关节炎的发展。中医通过改变OA的疾病和症状提供了医学价值。尽管众多成分之间复杂的相互作用网络表明了目标规范的不确定性，但利用现代技术探索OA患者中医优点的有价值的工作已经进行了研究。本文将对近5年来中药的作用机制进行综述，讨论中药在OA中的抗炎、抗凋亡、抗氧化、抗代谢和增殖等方面的作用。中医是OA治疗的建议医学选择。
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA. Valuable work on exploring TCM merits for OA patients has been investigated using modern technologies, although the complicated interacting network among the numerous components indicates the uncertainty of target specification. This review will provide an overview of the action mechanism of TCM in the last 5 years, discussing the TCM activities of anti-inflammation, antiapoptosis, antioxidation, anticatabolism, and proliferation in OA. TCM is a proposed medical option for OA treatment.