Effect of particulate air, pollution on lung function in adult and pediatric subjects in a Seattle panel study
Effect of particulate air, pollution on lung function in adult and pediatric subjects in a Seattle panel study
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DOI：
10.1378/chest.129.6.1614
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发表时间：
2006-06-01
期刊：
影响因子：
9.6
通讯作者：
Koenig, Jane Q.
中科院分区：
文献类型：
--
作者：
Trenga, Carol A.;Sullivan, Jeffrey H.;Koenig, Jane Q.
研究目的：为了确定通过个人、住宅或中心站点监测测量的颗粒物空气污染（PM）暴露增加是否与COPD成人或哮喘儿童的肺功能下降相关。参与者：我们在西雅图对57名患有或不患有COPD的成人和17名6至13岁的儿童进行了为期3年的研究，研究设计和测量：在受试者家中进行室内和室外PM测量。受试者连续10个24小时佩戴个人暴露监测器，并在室外中心位置测量PM。我们评估了受试者内颗粒暴露对成人FEV1和呼气峰流速（PEF）的影响，以及对儿童最大呼气中段流速（MMEF）、PEF、FEV1和症状的影响。
Study objective: To determine whether increased exposure to particulate matter air pollution (PM), measured with personal, residential, or central site monitoring, was associated with pulmonary function decrements in either adults with COPD or children with asthma.Participants: We studied 57 adults with or without COPD and 17 children aged 6 to 13 years with physician-diagnosed asthma in Seattle during a 3-year panel study.Study design and measurements: Indoor and outdoor PM measurements were made at subjects' homes. The subjects wore personal exposure monitors for 10 consecutive 24-h periods, and PM was also measured at a central outdoor location. We assessed the within-subject effect of particulate exposure on FEV1 and peak expiratory flow (PEF) in adults, and maximal midexpiratory flow (MMEF), PEF, FEV1, and symptoms in children.Results: FEV1 decrements were associated with 1-day lagged central site PM