Pharmacokinetics of the monoclonal antibody B72.3 and its fragments labeled with either 125I or 111In.
Pharmacokinetics of the monoclonal antibody B72.3 and its fragments labeled with either 125I or 111In.
复制标题
单克隆抗体 B72.3 及其用 125I 或 111In 标记的片段的药代动力学。
作者：
B. Brown;R. Comeau;P. L. Jones;F. A. Liberatore;W. Neacy;H. Sands;B. Gallagher
在带有靶点 (LS174T) 和非靶点 (HCT-15) 肿瘤的无胸腺小鼠中，对完整 B72.3（一种针对人乳腺癌和结肠癌特异性的鼠单克隆抗体）与用 111In 和 125I 标记的 F(ab')2 和 Fab 片段的药代动力学进行了比较。 IgG B72.3 用任一同种型成像 LS174T 标记。除肝脏外，所有器官中两种标记的生物分布相似。 F(ab')2 也对 LS174T 肿瘤进行了成像，而带有任一同种型的 Fab 则没有。对于两种同位素，血液清除率是 Fab 大于 F(ab')2 大于免疫球蛋白 G B72.3。 111In标记的碎片在肾脏中产生大量积聚，并持续2天。用两种同位素标记的各种形式的 B72.3 的不同生物分布模式表明，片段和同位素的最理想组合将取决于预期用途。
A comparison of the pharmacokinetics of intact B72.3 (a murine monoclonal antibody specific for human breast and colon carcinoma) with F(ab')2 and Fab fragments labeled with 111In and 125I was done in athymic mice bearing target (LS174T) and non-target (HCT-15) tumors. IgG B72.3 labeled with either isotype imaged LS174T. Biodistributions of both labels were similar in all organs except liver. F(ab')2 also imaged the LS174T tumor, while Fab bearing either isotype did not. The blood clearance was Fab greater than F(ab')2 greater than immunoglobulin G B72.3 for both isotopes. 111In-labeled fragments yielded large accumulations in the kidneys which persisted for 2 days. The different patterns of biodistribution for the various forms of B72.3 labeled with the two isotopes suggest that the most desirable combination of fragment and isotope will depend on the intended use.
通过针对结肠癌的放射性标记单克隆抗体对患者进行肿瘤定位。
影响因子：
11.2
作者：
Mach,JP;Chatal,JF;Lumbroso,JD;Buchegger,F;Forni,M;Ritschard,J;Berche,C;Douillard,JY;Carrel,S;Herlyn,M
通讯作者：
Herlyn,M
111In 标记单克隆抗肿瘤抗体在正常动物和裸鼠-人肿瘤模型中的稳定性、表征和动力学。
影响因子：
11.2
作者：
Halpern,SE;Hagan,PL;Garver,PR;Koziol,JA;Chen,AW;Frincke,JM;Bartholomew,RM;David,GS;Adams,TH
通讯作者：
Adams,TH