Circulating YKL-40 levels during human endotoxaemia
Circulating YKL-40 levels during human endotoxaemia
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DOI：
10.1111/j.1365-2249.2005.02763.x
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发表时间：
2005-05-01
影响因子：
4.6
通讯作者：
Pedersen, BK
中科院分区：
文献类型：
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作者：
Johansen, JS;Krabbe, KS;Pedersen, BK
YKL-40由巨噬细胞和中性粒细胞分泌，细菌感染患者循环YKL-40升高。目的是评估8名健康志愿者在注射大肠杆菌内毒素或生理盐水后血浆YKL-40（通过酶联免疫吸附试验（ELISA）测定）在0、2、4、8、24和32 h的变化。内毒素注射后24 h血浆YKL-40从31 μ g/l（范围19 ~ 39 μ g/l）升高至159 μ g/l（范围61 ~ 552 μ g/l， P < 0.01），与生理盐水相比，内毒素注射后血浆YKL-40升高（P < 0.001），提示YKL-40在感染中具有功能作用。
YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia coli endotoxin or saline. Plasma YKL-40 increased after endotoxin injection from 31 mu g/l (range 19-39 mu g/l) to a maximum of 159 mu g/l (61-552 mu g/l, P < 0.01) at 24 h. The finding that plasma YKL-40 increased after endotoxin injection compared with saline (P < 0.001) suggests that YKL-40 has a functional role in infections.