Function and pathological implications of exon junction complex factor Y14.
Function and pathological implications of exon junction complex factor Y14.
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DOI：
10.3390/biom5020343
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发表时间：
2015-04-10
期刊：
影响因子：
5.5
通讯作者：
Tarn WY
中科院分区：
文献类型：
--
作者：
Chuang TW;Lee KM;Tarn WY
真核生物信使核糖核酸的生物发生涉及一系列相互关联的步骤，包括核前信使核糖核酸加工、信使核糖核酸输出和监测。外显子连接复合体(EJC)沉积在新剪接的mRNAs上，协调mRNA生物发生的几个下游步骤。EJC核心蛋白Y14与其合作伙伴一起，在无意义介导的mRNA衰退和翻译增强中发挥作用。Y14在mRNA代谢中发挥着额外的作用，其中一些作用不依赖于EJC，它还参与了其他的细胞过程。Y14的基因突变或表达异常会导致生理异常，并可能导致疾病。因此，了解Y14的各种功能及其生理和病理作用是非常重要的。
Eukaryotic mRNA biogenesis involves a series of interconnected steps, including nuclear pre-mRNA processing, mRNA export, and surveillance. The exon-junction complex (EJC) is deposited on newly spliced mRNAs and coordinates several downstream steps of mRNA biogenesis. The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement. Y14 plays additional roles in mRNA metabolism, some of which are independent of the EJC, and it is also involved in other cellular processes. Genetic mutations or aberrant expression of Y14 results in physiological abnormality and may cause disease. Therefore, it is important to understand the various functions of Y14 and its physiological and pathological roles.