Competition for shared resources increases dependence on initial population size during coalescence of gut microbial communities.
Competition for shared resources increases dependence on initial population size during coalescence of gut microbial communities.
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在肠道微生物群落合并过程中，对共享资源的竞争增加了对初始种群规模的依赖。
DOI：
10.1101/2023.11.29.569120
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Huang,KerwynCasey
中科院分区：
文献类型：
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作者：
Goldman,DoranA;Xue,KatherineS;Parrott,AutumnB;Jeeda,RashiR;Franzese,LaurynR;Lopez,JaimeG;Vila,JeanCC;Petrov,DmitriA;Good,BenjaminH;Relman,DavidA;Huang,KerwynCasey
物种引进的结果取决于繁殖体的大小和资源竞争，但这些因素的影响在不同的群落环境中并不一致。在这里，我们通过以超过七个数量级的比例混合体外肠道微生物群落对，研究繁殖体大小和资源竞争如何相互作用，从而在群落合并过程中形成定植。每个产生的共培养物含有相对丰度取决于接种剂量的物种，导致一些共培养物的组成在混合比例上有很大变化，甚至在> 30代生长后也是如此。使用消费者资源模型，我们表明，当生态位重叠度很高并且物种对共享资源的竞争接近中性时，就会出现剂量依赖性定植。该模型成功地预测了菌株分离物混合物的结果，其中繁殖体大小在更多样化的群落中具有更大、更持久的影响。我们的研究建立了一个框架来预测繁殖体大小的环境依赖性影响，为微生物组疗法的设计提供原则。
The outcomes of species introductions depend on both propagule size and resource competition, but the effects of these factors are inconsistent across community contexts. Here, we investigate how propagule size and resource competition interact to shape colonization during community coalescence by mixing pairs of in vitro gut microbial communities at ratios that vary over seven orders of magnitude. Each resulting co-culture contained species whose relative abundance depended on inoculation dose, causing the composition of some co-cultures to vary substantially across mixture ratios, even after> 30 generations of growth. Using a consumer-resource model, we show that dose-dependent colonization can arise when niche overlap is high and species compete near-neutrally for shared resources. This model successfully predicts the outcomes of mixtures of strain isolates, in which propagule size has larger, longer-lasting effects in more diverse communities. Our study establishes a framework for predicting the context-dependent impacts of propagule size, providing principles for the design of microbiome therapeutics.