Presence of Human Papilloma Virus in a Series of Breast Carcinoma from Argentina
Presence of Human Papilloma Virus in a Series of Breast Carcinoma from Argentina
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DOI：
10.1371/journal.pone.0061613
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发表时间：
2013-04-25
期刊：
影响因子：
3.7
通讯作者：
Chabay, Paola
中科院分区：
文献类型：
--
作者：
Pereira Suarez, Ana Laura;Alejandro Lorenzetti, Mario;Chabay, Paola
背景：乳腺癌的发病机理和分子机制尚不清楚。最近的一些报告研究了人乳头瘤病毒（HPV）在这种疾病中的作用。本研究的目的是确定HPV在乳腺癌中的患病率。方法：对61例新鲜冷冻乳腺癌标本进行分析。用PCR检测样品的HPV，产品自动测序。结果与临床及病理特征相关。结果：乳腺癌样本中HPV DNA的检出率为26%（16/61）。临床参数与HPV感染无统计学相关性（p < 0.05）。一个亚组病例的序列分析显示低风险HPV11的患病率，其次是高风险HPV16。我们没有发现HPV转录活性。结论：目前的研究首次在阿根廷证明了HPV在恶性乳腺组织中的比例存在。这一发现提示HPV可能在乳腺癌发生中具有生物学意义。
Background: The etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the prevalence of HPV in breast cancer.Methods: Sixty one fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were automatically sequenced. Findings were correlated with clinical and pathological characteristics.Results: The HPV DNA prevalence in the breast cancer samples was 26% (16/61). Clinical parameters were not statistically associated with HPV presence (p>0.05 chi(2) test). Sequence analysis in a subgroup of cases indicates the prevalence of low risk HPV11, followed by high risk HPV16. We found no HPV transcriptional activity.Conclusion: The present study demonstrated for the first time in Argentina the presence of HPV in a proportion of the malignant breast tissues. This finding suggests that HPV may have a biological significance in breast carcinogenesis.