Use of Ring-Expanded Diamino- and Diamidocarbene Ligands in Copper Catalyzed Azide-Alkyne "Click" Reactions
Use of Ring-Expanded Diamino- and Diamidocarbene Ligands in Copper Catalyzed Azide-Alkyne "Click" Reactions
复制标题
DOI：
10.1021/om5004732
复制
发表时间：
2014-10-27
期刊：
影响因子：
2.8
通讯作者：
Whittlesey, Michael K.
中科院分区：
文献类型：
--
作者：
Collins, Lee R.;Rookes, Thomas M.;Whittlesey, Michael K.
合成了双配位扩环N-杂环卡宾铜(I)配合物[Cu(RE-NHC)(2)](+)(RE-NHC=6-MES，7-O-Tol，7-MES)，并研究了它们在纯净条件下对炔烃和叠氮化物的1，3-偶极环加成反应的催化性能。相反，阳离子二胺卡宾类似物[Cu(6-MesDAC)(2)](+)和中性物种[(6-MesDAC)CuCL](2)和[(6-MesDAC)(2)(CuCL)(3)]在水上催化时表现出良好的催化活性。
The two-coordinate ring-expanded N-heterocyclic carbene copper(I) complexes [Cu(RE-NHC)(2)](+) (RE-NHC = 6-Mes, 7-o-Tol, 7-Mes) have been prepared and shown to be effective catalysts under neat conditions for the 1,3-dipolar cycloaddition of alkynes and azides. In contrast, the cationic diamidocarbene analogue [Cu(6-MesDAC)(2)](+) and the neutral species [(6-MesDAC)CuCl](2) and [(6-MesDAC)(2)(CuCl)(3)] show good activity when the catalysis is performed on water.