Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract
Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract
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DOI：
10.1007/s10787-008-8038-3
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发表时间：
2009-02-01
影响因子：
5.8
通讯作者：
Asmawi, M. Z.
中科院分区：
文献类型：
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作者：
Yam, M. F.;Ang, L. F.;Asmawi, M. Z.
冬虫夏草标准甲醇/水(50/50)提取物的解热活性。以SD大鼠为实验动物，研究了SEOS对正常体温和酵母菌引起的发热的影响。SEOS对正常体温没有影响。剂量为500 mg/kg和1000 mg/kg的SEOS可显著降低酵母引起的体温升高。这种作用在给药后持续到4h。SEOS的解热作用与标准解热剂扑热息痛(150 mg/kg P.O.)相当。高效液相色谱分析表明，SEOS中含有迷迭香酸7.58%、芥子皂苷0.2%、尤普香素0.34%和四甲氧基黄酮0.24%。提取物对大鼠的LD_(50)>5000 mg/kg体重。因此，本研究确定SEOS具有显著的解热活性。
The anti-pyretic activity of a standardized methanol/water (50/50) extract of Orthosiphon stamineus Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD50 of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity.