Levels and correlates of alpha-fetoprotein in normal pregnancies among Caucasian and Chinese women.
Levels and correlates of alpha-fetoprotein in normal pregnancies among Caucasian and Chinese women.
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白种人和中国女性正常妊娠时甲胎蛋白的水平和相关性。
DOI：
10.1097/01.cej.0000228414.00634.53
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Hsieh,Chung-Cheng
中科院分区：
文献类型：
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作者：
Lagiou,Pagona;Samoli,Evangelia;Lagiou,Areti;Lambe,Mats;Trichopoulos,Dimitrios;Adami,Hans-Olov;Hsieh,Chung-Cheng
甲胎蛋白被认为在成年和子宫内都具有抗乳腺癌的特性。我们研究了正常单胎妊娠孕妇血清甲胎蛋白水平的相关性。这是一项前瞻性研究，依赖于在美国波士顿和中国上海的主要教学医院参加产科的妇女。具体而言，波士顿的212名白人妇女和上海的196名亚洲妇女在妊娠第16周和第27周提供了血液样本。测量母体血清甲胎蛋白水平，并通过多元回归程序将其与母体和新生儿参数相关联，控制一组潜在的混杂因素，包括母体测量的激素水平。甲胎蛋白与母体孕前体重指数呈强负相关（第27周时每1 kg/m2体重指数为− 4.73 ng/l，95%置信区间为− 7.09至− 2.36），而与产次、后代性别或出生体重无关。妊娠持续时间与母体甲胎蛋白水平呈负相关，尤其是在高加索女性中（第27周时，每60 ng/l甲胎蛋白为− 0.22周，95%置信区间为− 0.39至− 0.05）。在正常妊娠中，母体甲胎蛋白与孕前体重指数呈负相关，并且似乎对妊娠期而不是出生体重具有生理作用。
Alpha-fetoprotein has been suggested to have anti breast cancer properties both in adult life and in utero. We studied correlates of maternal serum α-fetoprotein levels in normal singleton pregnancies. This was a prospective study relying on women attending maternal units in major teaching hospitals in Boston, USA and Shanghai, China. Specifically, 212 Caucasian women in Boston, and 196 Asian women in Shanghai provided blood samples at the 16th and 27th gestational week. Maternal serum α-fetoprotein levels were measured and correlated with maternal and newborn parameters through multiple regression procedures, controlling for a set of potential confounders, including maternal levels of measured hormones. Alpha-fetoprotein was strongly inversely associated with maternal prepregnancy body mass index (− 4.73 ng/l at the 27th week per 1 kg/m 2 of body mass index, with 95% confidence intervals− 7.09 to− 2.36), whereas it was not related to parity, gender of offspring or birth weight. Duration of gestation was inversely associated with maternal α-fetoprotein levels, particularly among Caucasian women (− 0.22 weeks per 60 ng/l of α-fetoprotein at the 27th week, with 95% confidence intervals− 0.39 to− 0.05). In normal pregnancies, maternal α-fetoprotein is inversely related to prepregnancy body mass index and appears to have a physiologic role on duration of gestation rather than on birth weight.