An unusual mechanism for ligand antagonism
An unusual mechanism for ligand antagonism
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DOI：
10.1126/science.281.5376.568
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发表时间：
1998-07-24
期刊：
影响因子：
56.9
通讯作者：
Metzger, H
中科院分区：
文献类型：
--
作者：
Torigoe, C;Inman, JK;Metzger, H
The ratio of late to early events stimulated by the mast cell receptor for immunoglobulin E (IgE) correlated with the affinity of a ligand for the receptor-bound IgE. Because excess receptors clustered by a weakly binding ligand could hoard a critical initiating kinase, they prevented the outnumbered clusters engendered by the high-affinity ligands from launching the more complete cascade. A similar mechanism could explain the antagonistic action of some peptides on the activation of T cells.
