In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis
In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis
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DOI：
10.1128/aac.49.6.2510-2511.2005
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发表时间：
2005-06-01
影响因子：
4.9
通讯作者：
Saiman, L
中科院分区：
文献类型：
--
作者：
Chen, YH;Garber, E;Saiman, L
从囊性纤维化患者分离的多重耐药铜绿假单胞菌(n=200)、非粘液型铜绿假单胞菌(n=200)和复合型洋葱伯克霍尔德菌(n=200)对多药耐药菌多药耐药株的MIC50和MIC90分别为8和32、8和和8和32µg/ml。多利培南的活性略好于已有的抗菌剂。
Doripenem 50% inhibitory concentrations (MIC50) and 90% inhibitory concentrations (MIC90) for multidrug-resistant strains of mucoid Pseudomonas aeruginosa (n = 200 strains), nonmucoid P. aeruginosa (n = 200), and Burkholdetia cepacia complex (n = 200) isolated from patients with cystic fibrosis were 8 and 32, 8 and 64, and 8 and 32 mu g/ml, respectively. Doripenem had somewhat better activity than established antimicrobial agents.