Blood born viral infections, sexually transmitted diseases and latent tuberculosis in italian prisons: a preliminary report of a large multicenter study.
Blood born viral infections, sexually transmitted diseases and latent tuberculosis in italian prisons: a preliminary report of a large multicenter study.
复制标题
意大利监狱中的血源性病毒感染、性传播疾病和潜伏性结核病：一项大型多中心研究的初步报告。
DOI：
--
复制
发表时间：
2012
影响因子：
3.3
通讯作者：
S. Babudieri
中科院分区：
文献类型：
--
作者：
E. Sagnelli;G. Starnini;C. Sagnelli;R. Monarca;G. Zumbo;E. Pontali;A. Gabbuti;S. Carbonara;R. Iardino;O. Armignacco;S. Babudieri
背景
最近对囚犯进行的丙型肝炎病毒(丙型肝炎病毒)、乙肝病毒(乙肝病毒)、人类免疫缺陷病毒(HIV)、梅毒和潜伏结核病(LTB)的筛查没有提供足够的信息来改进保健策略。
目标
获取关于意大利监狱中上述感染的地方性的宝贵信息。
材料和方法
采用点对点的方式进行筛查，自愿采血1个月，检测上述5种感染中的4种，用PPD(纯蛋白衍生品)皮试检测LTB。本分析涉及在20所监狱中的9所监狱获得的数据。
结果
不同监狱接受筛查的患者比例不同(37.3-95.2%，中位数62.2)，但高于干预前相同9所监狱采用传统方法获得的10.0-20.5%。筛查参与率分别为：乙肝65.3%、丙型肝炎64.6%、HIV 67.4%、梅毒螺旋体血凝试验55.7%、LTB 42.8%。在2265名受试者中检出了4.4%的乙肝表面抗原，在2241名受检者中检出了22.8%的抗-HCV，在2339名受检者中检出了3.8%的抗-HIV，在1932名中检出了2.1%的TPHA，在1486名受检者中PPD皮试阳性率为17.2%。筛查确定了183名不明感染的受试者，56名意大利人和127名外国人接受临床决策评估：35人患有乙肝病毒慢性感染，34人患有丙型肝炎病毒慢性感染，3人抗-HIV阳性，14人梅毒，97人患有LTB。
结论
新的筛查方法以点对点交流为基础，然后在自愿的基础上进行血液采样，为改善每一所监狱的医疗保健系统提供了宝贵的信息。
BACKGROUND
Recent screenings of inmates for Hepatitis C virus (HCV), Hepatitis B virus (HBV), human immunodeficiency virus (HIV), Syphilis and Latent Tuberculosis (LTB) did not provide sufficient information to improve healthcare strategies.
AIM
To obtain valuable information on the endemicity of the above mentioned Infections in prisons of Italy.
MATERIALS AND METHODS
A screening based on a peer-to-peer communication, followed by a month of blood sampling on a voluntary basis was performed to detect antibody to 4 of the 5 above mentioned infections and detect LTB by PPD (purified protein derivative) Skin Test. The present analysis regards data obtained in 9 of the 20 prisons.
RESULTS
The percentage of patients who accepted the screening varied between jails (37.3-95.2%, median 62.2), but it was higher than 10.0-20.5% obtained in the same 9 prisons using traditional methods before our intervention. The participation to the screening reached 65.3% for HBV, 64.6% for HCV, 67.4%for HIV, 55.7% for TPHA (Treponema Pallidum Hemagglutination Assay) and 42.8% for LTB. HBsAg was detected in 4.4% of 2265 subjects, anti-HCV in 22.8% of 2241, anti-HIV in 3.8% of 2339 and TPHA in 2.1% of 1932; PPD Skin Test was positive in 17.2% of 1486 subjects. The screening identified 183 subjects with an unknown infection, 56 italian and 127 foreigners to be evaluated for clinical decisions: 35 with HBV chronic infection, 34 with HCV chronic infection, 3 anti-HIV positive, 14 with syphilis and 97 with LTB.
CONCLUSIONS
The new approach to the screening, based on a peer-to-peer communication followed by blood sampling on a voluntary basis provided valuable information to improve the healthcare system in each single prison.