Renal denervation ameliorates post-infarction cardiac remodeling in rats through dual regulation of oxidative stress in the heart and brain
Renal denervation ameliorates post-infarction cardiac remodeling in rats through dual regulation of oxidative stress in the heart and brain
复制标题
去肾神经通过心脏和大脑氧化应激的双重调节改善大鼠梗死后心脏重塑
DOI：
10.1016/j.biopha.2019.109243
复制
发表时间：
2019-10-01
影响因子：
7.5
通讯作者：
Shan, Qi-Jun
中科院分区：
文献类型：
--
作者：
Jiang, Wan-Ying;Huo, Jun-Yu;Shan, Qi-Jun
背景：心肌重构是缺血性心肌病发生发展的关键环节。目的：比较去肾神经（RDN）和血管紧张素受体脑啡肽酶抑制剂（ARNi）对心肌梗死（MI）后心脏重构的影响，并探讨其机制。从MI后1周开始，以60 mg/kg/天的剂量施用ARNi，持续4周。MI后1周进行RDN/假RDN手术。MI后5周对所有组的大鼠进行研究。超声心动图评价心功能。Masson染色和TUNEL染色检测心肌重塑程度。结果：MI后5周，RDN和ARNi均能显著改善心功能和心脏重构，但RDN在抑制心肌细胞凋亡方面上级优于ARNi。与ARNi相比，RDN也更有效地减少心肌梗死引起的异常氧化应激，这是特别真实的情况下，大脑和证实的反应性氧自由基（ROS）水平和其他氧化应激参数的变化后MI。结论：RDN是不逊色于ARNi在改善缺血性心肌病大鼠的心脏重塑。RDN的作用可能与有效抑制心脏和大脑的氧化应激有关。
Background: Myocardial remodeling is the key step in the development of ischemic cardiomyopathy. We aimed to compare effects of renal denervation (RDN) with those of angiotensin receptor neprilysin inhibitors (ARNi) on cardiac remodeling after myocardial infarction (MI), and explore underlying mechanism.Methods: Sprague-Dawley rats (n = 40; male) were subjected to ligation of left anterior descending coronary artery to induce MI; six rats served as controls. ARNi was administered at a dose of 60 mg/kg/day for 4 weeks starting 1 week after MI. An RDN/Sham-RDN procedure was performed 1 week after MI. Rats in all groups were studied 5 weeks after MI. Echocardiography was used to evaluate cardiac function. Masson staining and TUNEL staining were used to determine the extent of cardiac remodeling. Indicators of oxidative stress in heart and brain were used to analyze the potential mechanisms involved.Results: Five weeks after MI, both RDN and ARNi significantly improved cardiac function and cardiac remodeling; however, RDN was superior to ARNi at attenuating myocardial apoptosis. Compared to ARNi, RDN was also more effective at decreasing the abnormal oxidative stress caused by MI; this was especially true in case of the brain and was confirmed by evaluating the changes in reactive oxygen species (ROS) levels and other oxidative stress parameters following MI.Conclusions: RDN is not inferior to ARNi with respect to the improvement of cardiac remodeling in rats with ischemic cardiomyopathy. The effect of RDN might be associated with effective inhibition of oxidative stress in both the heart and brain.