SAFETY OF INFLUENZA VACCINATION IN ALLERGIC CHILDREN
SAFETY OF INFLUENZA VACCINATION IN ALLERGIC CHILDREN
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DOI：
10.1093/infdis/136.supplement_3.s652
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发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
FOX, JP
中科院分区：
文献类型：
--
作者：
BIERMAN, CW;SHAPIRO, GG;FOX, JP
研究了142名3 ~ 18岁的过敏儿童，以评估流感疫苗皮肤试验的有效性，作为识别那些尽管对鸡、鸡蛋或羽毛过敏但可以安全接种疫苗的儿童的一种手段。128名儿童接受了全面免疫。使用二价流感A/新泽西/76-A/维多利亚/75疫苗。12名儿童皮肤试验呈阳性，但没有接种疫苗，两名儿童在第一次注射后皮肤试验呈阳性。一名儿童在8小时后出现荨麻疹，一名儿童出现非特异性反应，一名儿童在第二次注射后8天出现自限性多形性红斑反应。所有其他人都能很好地耐受手术。对鸡蛋的敏感性史不是疫苗敏感性的可靠指标，因为疫苗的皮肤试验。用1：100稀释的疫苗在生理盐水中进行皮内皮肤试验的阴性结果似乎是过敏受试者的可靠指标，这些受试者可以接种流感疫苗，而不必担心危及生命的急性过敏反应。
One hundred forty-two allergic children aged three to 18 years were studied for evaluation of the usefulness of skin testing with influenza vaccine as a means of identifying those children who could be immunized safely despite their allergies to chickens, eggs, or feathers. One hundred twenty-eight children were fully immunized. with bivalent influenza A/New Jersey/76-A/Victoria/75 vaccine. Twelve children had positive skin tests and were not immunized, and two developed positive skin tests after their first injection. One child had urticaria 8 hr later, one had a nonspecific reaction, and one had a self-limited erythema multiforme reaction eight days after the second injection. All others tolerated the procedure well. History of sensitivity to eggs was not as reliable an indication of vaccine sensitivity as skin testing with vaccine. A negative result of an intradermal skin test with a 1:100 dilution of the vaccine in saline appeared to be a reliable indicator of allergic subjects who could be immunized against influenza without fear of life-threatening acute allergic reactions.