Levels of serum vitamin A, alpha-tocopherol and malondialdehyde in patients with non-alcoholic steatohepatitis: relationship with histopathologic severity
Levels of serum vitamin A, alpha-tocopherol and malondialdehyde in patients with non-alcoholic steatohepatitis: relationship with histopathologic severity
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DOI：
10.1111/j.1742-1241.2004.00312.x
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发表时间：
2005-03-01
影响因子：
2.6
通讯作者：
Ozercan, IH
中科院分区：
文献类型：
--
作者：
Bahcecioglu, IH;Yalniz, M;Ozercan, IH
本研究的目的是评估非酒精性脂肪性肝炎（NASH）患者血清丙二醛（MDA）、维生素A和α -生育酚的抗氧化剂水平，并确定它们与组织病理严重程度的关系。29例活检证实的NASH患者被纳入研究。对NASH进行组织病理学评分，进行分级和分期。与健康对照组相比，NASH合并单纯性脂肪变性患者血清MDA和维生素A水平升高。单纯性脂肪变性和NASH患者血清α -生育酚水平显著低于健康对照组，0-1级和2-3级患者血清MDA、维生素A和α -生育酚水平无显著差异。单纯性脂肪变性和NASH患者血清MDA和维生素A水平升高。NASH患者的丙二醛、维生素A和α -生育酚水平与组织病理严重程度无关。
The aims of our study were to estimate serum levels of malondialdehyde (MDA), serum levels of vitamin A and alpha -tocopherol as antioxidants and determine relationship of these with histopathologic severity in patients with non-alcoholic steatohepatitis (NASH).Twenty-nine patients with biopsy-proven NASH were included to study. NASH were histopathologically scored for grading and staging. Serum MDA and vitamin A levels were increased in patients with NASH and simple steatosis as compared to healthy control group. Serum alpha-tocopherol levels measured in simple steatosis and NASH were significantly lower than in healthy control group There was no significant difference between grade/stage 0-1 and grade/stage 2-3 in terms of MDA, vitamin A and alpha-tocopherol levels. Serum MDA and vitamin A levels are increased in simple steatosis and NASH. MDA, vitamin A and alpha-tocopherol levels in NASH were not associated with the histopathologic severity.