Survival of reproductive behaviors in estrogen receptor β gene-deficient (βERKO) male and female mice
Survival of reproductive behaviors in estrogen receptor β gene-deficient (βERKO) male and female mice
复制标题
DOI：
10.1073/pnas.96.22.12887
复制
发表时间：
1999-10-26
影响因子：
11.1
通讯作者：
Pfaff, DW
中科院分区：
文献类型：
--
作者：
Ogawa, S;Chan, J;Pfaff, DW
此前，有研究表明，雌激素受体(ER)α基因(ERα)的缺失极大地影响了雌性和雄性小鼠的生殖相关行为。然而，新的第二个ER基因ERβ的广泛表达要求我们研究ERβ可能参与这些行为的调节。与我们的结果形成鲜明对比的是，ERα基因敲除(Alpha Erko)雄性在性行为测试中的表现至少与野生型对照一样好。此外，贝塔Erko雄性不仅表现出正常的雄性典型攻击行为，包括攻击性攻击，而且在某些社会经验条件下，它们也表现出比野生型小鼠更高的攻击性水平。这些数据表明，在攻击性行为方面，基因型和社会经验之间存在显著的交互作用。最后，携带雌激素受体基因功能β亚型的雌性动物表现出正常的前凸和求偶行为，在某些情况下会延续到行为发情期之后。这些结果突出了ERα对两性自然生殖行为正常表达的重要性，也为进一步研究ERβ基因对其他非生殖行为的贡献提供了背景。
Previously, it was shown that the lack of a functional estrogen receptor (ER) alpha gene (ER alpha) greatly affects reproduction-related behaviors in both female and male mice. However, widespread expression of a novel second ER gene, ER beta, demanded that we examine the possible participation of ER beta in regulation of these behaviors. In dramatic contrast to our results with ER alpha knockout (alpha ERKO) males, beta ERKO males performed at least as well as wildtype controls in sexual behavior tests. Moreover, not only did beta ERKO males exhibit normal male-typical aggressive behavior, including offensive attacks, but they also showed higher levels of aggression than wild-type mice under certain conditions of social experience. These data revealed a significant interaction between genotype and social experience with respect to aggressive behavior. Finally, females racking a functional beta isoform of the ER gene showed normal lordosis and courtship behaviors, extending in some cases beyond the day of behavioral estrus. These results highlight the importance of ER alpha for the normal expression of natural reproductive behaviors in both sexes and also provide a background for future studies evaluating ER beta gene contributions to other, nonreproductive behaviors.