Multi-pulse drug delivery from a resorbable polymeric microchip device
Multi-pulse drug delivery from a resorbable polymeric microchip device
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DOI：
10.1038/nmat998
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发表时间：
2003-11-01
期刊：
影响因子：
41.2
通讯作者：
Langer, R
中科院分区：
文献类型：
--
作者：
Grayson, ACR;Choi, IS;Langer, R
控释给药系统有许多应用，包括治疗激素缺乏症和慢性疼痛。一种能够提供多剂量给药的可生物降解装置对于需要脉冲式药物释放的疾病的长期治疗是有利的。在这项工作中，制造了可生物降解的聚合物微芯片，它在体外能释放四脉冲的放射性标记的葡聚糖、人生长激素或肝素。在142天内释放的肝素平均保留了其96±12%的生物活性。微芯片直径为1.2厘米，厚480 - 560微米，有36个储库，每个储库可填充不同的化学物质。这些装置由聚（L - 乳酸）制成，并且具有覆盖储库的不同分子量的聚（D，L - 乳酸 - 羟基乙酸）膜。通过使用不同分子量或材料的膜，可以设计一种给药系统，使其在植入患者体内后有潜力按间隔释放不同药物的脉冲。
Controlled-release drug delivery systems have many applications, including treatments for hormone deficiencies and chronic pain. A biodegradable device that could provide multi-dose drug delivery would be advantageous for long-term treatment of conditions requiring pulsatile drug release. In this work, biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro. Heparin that was released over 142 days retained on average 96+/-12% of its bioactivity. The microchips were 1.2 cm in diameter, 480-560 mum thick and had 36 reservoirs that could each be filled with a different chemical. The devices were fabricated from poly(L-lactic acid) and had poly(D,L-lactic-co-glycolic acid) membranes of different molecular masses covering the reservoirs. A drug delivery system can be designed with the potential to release pulses of different drugs at intervals after implantation in a patient by using different molecular masses or materials for the membrane.