Frequency‑Specific Regional Homogeneity Alterations and Cognitive Function in Obstructive Sleep Apnea Before and After Short-Term Continuous Positive Airway Pressure Treatment.
Frequency‑Specific Regional Homogeneity Alterations and Cognitive Function in Obstructive Sleep Apnea Before and After Short-Term Continuous Positive Airway Pressure Treatment.
复制标题
频率——短期持续气道正压通气治疗前后阻塞性睡眠呼吸暂停的特定区域均匀性改变和认知功能
DOI：
10.2147/nss.s344842
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发表时间：
2021
影响因子：
3.4
通讯作者：
Peng D
中科院分区：
文献类型：
--
作者：
Li H;Li L;Kong L;Li P;Zeng Y;Li K;Xie W;Shu Y;Liu X;Peng D
以往的研究表明，阻塞性睡眠呼吸暂停（OSA）患者在常规频段（0.01-0.08 Hz）存在异常的局部自发脑活动。然而，目前尚不清楚这些异常是否与低频振荡的特定频带有关，或者是否可以通过持续气道正压通气（CPAP）治疗来改善。本研究旨在调查OSA患者在基线（CPAP前）和CPAP依从性治疗一个月后（CPAP后）特定频率的区域同质性（ReHo）。21例中重度OSA患者和21例年龄和性别匹配的健康对照（HC）被纳入最终分析。分别在三个不同的频带（典型频带：0.01-0.1 Hz;慢-5频带：0.01-0.027 Hz;慢-4频带：0.027-0.073 Hz）中计算ReHo。进行了部分相关分析，以评估ReHo改变与临床评价之间的关系。与HC组相比，OSA组脑干、双侧颞下回（ITG）/梭状回和右侧小脑后叶（CPL）的ReHo在不同频段均增高，双侧顶下小叶（IPL）、右侧上级颞回（STG）和左侧中央前回（PG）的ReHo在不同频段均降低。CPAP治疗前后OSA患者双侧颞中回（MTG）、PG、额内侧回（MFG）、辅助运动区（SMA）、CPL、IPL、左侧上级额上回（SFG）、ITG、MTG、右侧STG的ReHo均发生明显变化，且与特定频段相关。CPAP前OSA患者特定频段的ReHo改变与Montreal认知评估评分、埃普沃思嗜睡量表和呼吸暂停低通气指数相关。这些结果表明，OSA在短期CPAP治疗前后存在频率相关的自发神经活动异常，这可能有助于更好地理解局部神经精神病理学，并可能作为临床CPAP治疗的潜在生物标志物。
Previous studies have demonstrated abnormal local spontaneous brain activity in the conventional frequency bands (0.01–0.08 Hz) in obstructive sleep apnea (OSA). However, it is not clear whether these abnormalities are associated with the specific frequency band of low-frequency oscillations or whether it can be improved with a continuous positive airway pressure (CPAP) treatment. This study aimed to investigate the regional homogeneity (ReHo) in specific frequency at baseline (pre-CPAP) and after one month of CPAP adherence treatment (post-CPAP) in OSA patients. Twenty-one patients with moderate-to-severe OSA and 21 age- and sex-matched healthy controls (HCs) were included in the final analysis. ReHo was calculated in three different frequency bands (typical frequency band: 0.01–0.1 Hz; slow-5 band: 0.01–0.027 Hz; slow-4 band: 0.027–0.073 Hz), respectively. A partial correlational analysis was performed to assess the relationship between altered ReHo and clinical evaluation. OSA patients revealed increased ReHo in the brainstem, bilateral inferior temporal gyrus (ITG)/fusiform, and right-cerebellum posterior lobe (CPL), and decreased ReHo in the bilateral inferior parietal lobule (IPL), right superior temporal gyrus (STG), and left precentral gyrus (PG) compared to HC groups in different frequency bands. Significantly changed ReHo in the bilateral middle temporal gyrus (MTG), PG, medial frontal gyrus (MFG), supplementary motor area (SMA), CPL, IPL, left superior frontal gyrus (SFG), ITG, MTG, and right STG were observed between post-CPAP and pre-CPAP OSA patients, which was associated with specific frequency bands. The altered ReHo in specific frequency bands was correlated with Montreal cognitive assessment score, Epworth sleepiness scale, and apnea hypopnea index in pre-CPAP OSA patients. These findings indicate that OSA has frequency-related abnormalities of spontaneous neural activity before and after short-term CPAP treatment, which might contribute to a better understanding of local neural psychopathology and may serve as potential biomarkers for clinical CPAP treatment.