High-frequency (8 to 16 kHz) reference thresholds and intrasubject threshold variability relative to ototoxicity criteria using a Sennheiser HDA 200 earphone
High-frequency (8 to 16 kHz) reference thresholds and intrasubject threshold variability relative to ototoxicity criteria using a Sennheiser HDA 200 earphone
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DOI：
10.1097/00003446-200104000-00009
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发表时间：
2001-04-01
期刊：
影响因子：
3.7
通讯作者：
Frank, T
中科院分区：
文献类型：
--
作者：
Frank, T
目的：本研究的第一个目的是确定高频（8至16 kHz）阈值标准化参考等效阈值声压级（RETSPL）的森海塞尔HDA 200耳机。本研究的第二个也可能是更重要的目的是确定使用Sennheiser HDA 200耳机重复高频阈值是否具有比阿莎1994耳毒性显著阈值偏移标准更低的受试者内阈值变异性。设计：高频阈值（8至16 kHz），获得100（50名男性，50名女性）听力正常（0.25至8 kHz）年轻成人（平均年龄21.2岁）使用Sennheiser HDA 200耳机进行四次单独测试。结果：每个测试阶段的平均和中位高频阈值相似，并随频率增加而增加。在每个频率，高频阈值没有显着（p > 0.05）不同的性别，测试耳，或测试会话。每个频率的中位数阈值与1998年中期ISO RETSPL相似;然而，大的标准偏差和宽的阈值分布表明非常高的受试者间阈值变异性，特别是在14和16 kHz下。通过找到每个可能的测试会话比较之间的阈值差异来确定阈值重复性（N = 6），大约98%的阈值差在8至14 kHz的临床可接受范围内（+/-10 dB）。每个受试者的第二、第三、第四次减去第一次测试也被发现可以确定受试者内阈值变异性是否小于阿莎1994标准，由于耳毒性导致的阈值偏移。结果表明，在任何频率下阈值偏移大于或等于20 dB的假阳性率为0%，在两个连续频率下阈值偏移>10 dB的假阳性率为2%。这项研究证实，高产量-使用SennheiserHDA 200耳机的0 dBHL频率听力计应该等于从8到16 kHz的1998年临时ISORETSPL。此外，因为重复阈值之间的差异在+/-10dB以内，并且根据阿莎1994标准，由于耳毒性引起的显著阈值偏移具有极低的假阳性率，SennheiserHDA 200耳机可用于连续监测，以确定对于接受潜在耳毒性药物治疗的患者是否发生了显著的高频阈值偏移。
Objective: The first purpose of this study was to determine high-frequency (8 to 16 kHz) thresholds for standardizing reference equivalent threshold sound pressure levels (RETSPLs) for a Sennheiser HDA 200 earphone. The second and perhaps more important purpose of this study was to determine whether repeated high-frequency thresholds using a Sennheiser HDA 200 earphone had a lower intrasubject threshold variability than the ASHA 1994 significant threshold shift criteria for ototoxicity.Design: High-frequency thresholds (8 to 16 kHz) were obtained for 100 (50 male, 50 female) normally hearing (0.25 to 8 kHz) young adults (mean age of 21.2 yr) in four separate test sessions using a Sennheiser HDA 200 earphone.Results: The mean and median high-frequency thresholds were similar for each test session and increased as frequency increased. At each frequency, the high-frequency thresholds were not significantly (p > 0.05) different for gender, test ear, or test session. The median thresholds at each frequency were similar to the 1998 interim ISO RETSPLs; however, large standard deviations and wide threshold distributions indicated very high intersubject threshold variability, especially at 14 and 16 kHz, Threshold repeatability was determined by finding the threshold differences between each possible test session comparison (N = 6), About 98% of all of the threshold differences were within a clinically acceptable range of +/-10 dB from 8 to 14 kHz, The threshold differences between each subject's second, third, and fourth minus their first test session were also found to determine whether intrasubject threshold variability was less than the ASHA 1994 criteria for determining a significant threshold shift due to ototoxicity. The results indicated a false-positive rate of 0% for a threshold shift greater than or equal to 20 dB at any frequency and a false-positive rate of 2% for a threshold shift >10 dB at two consecutive frequencies.Conclusions: This study verified that the output of high-frequency audiometers at 0 dB HL using Sennheiser HDA 200 earphones should equal the 1998 interim ISO RETSPLs from 8 to 16 kHz, Further, because the differences between repeated thresholds were well within +/-10 dB and had an extremely low false-positive rate in reference to the ASHA 1994 criteria for a significant threshold shift due to ototoxicity, a Sennheiser HDA 200 earphone can be used for serial monitoring to determine whether significant high-frequency threshold shifts have occurred for patients receiving potentially ototoxic drug therapy.