A hollow-structured nanohybrid: Intelligent and visible drug delivery and photothermal therapy for cancer
A hollow-structured nanohybrid: Intelligent and visible drug delivery and photothermal therapy for cancer
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中空结构纳米杂化物：智能可见的药物输送和癌症光热疗法
DOI：
10.1016/j.talanta.2020.120893
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发表时间：
--
期刊：
影响因子：
6.1
通讯作者：
Yang Zhang
中科院分区：
文献类型：
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作者：
Lu Yang;Bo Hu;Ai-Hua Liu;Yang Zhang
制备多功能纳米载体在肿瘤治疗药物输送方面具有重要的应用价值。本文设计并合成了中空结构的hCu 2-xS@Au纳米壳/卫星复合物，并将其用于阿霉素的智能化、可视化给药和光热治疗。通过修饰hCu 2-xS@Au纳米颗粒表面的二硫键桥连的Au纳米壳和多羧基石墨烯量子点（MC-GOD），癌细胞/组织中的高浓度谷胱甘肽和低pH均可诱导响应性药物释放。在808 nm近红外（NIR）激光照射下，hCu 2-xS@Au@MC-GODs的光热转换效率为32%，这是由于Au纳米粒子修饰的hCuS的带隙减小，电子跃迁的电路路径增多，这与密度泛函理论有关，结合化疗和光热治疗大大提高了抗肿瘤的疗效。此外，当MC-GODs连接到hCu 2-xS@Au表面时，其荧光被猝灭/“关闭”，并且当MC-GODs从hCu 2-xS@Au表面脱离时，其荧光也被恢复/“打开”。MC-GODs的荧光开关既可以作为可控药物释放的“警卫”，也可以作为可视化监测的“眼睛”。这种多功能的治疗策略具有可控的药物输送，视觉监控和高光热转换效率的多模态治疗可能是预期的。
It is of great valuable in drug delivery to fabricate multifunctional nanovehicle for cancer therapy. Herein, hollow-structured hCu2-xS@Au nanoshell/satellite composite with doxorubicin-carrying was designed and synthesized for intelligent and visible drug delivery and satisfactory photothermal therapy. By modification of disulfide linkage bridged Au nanoshell and multi-carboxylic graphene quantum dots (MC-GODs) on the surface of hCu2-xS@Au nanoparticles, both the high concentration of glutathione and low pH in cancer cell/tissue can induce responsive drug release. The satisfactory photothermal conversion efficiency (32%) of hCu2-xS@Au@MC-GODs under 808 nm near-infrared (NIR) laser irradiation ascribed to the reduced bandgap and more circuit paths for electron transitions for hCuS modified with Au nanoparticles depend on density functional theory, which antitumor therapy efficacy was greatly enhanced by combining chemo- and photothermal therapy. Moreover, the fluorescence of MC-GODs was quenched/“turn off” as linking to the surface of hCu2-xS@Au, and also restored/“turn on” as the MC-GODs detaching from the surface of hCu2-xS@Au. The fluorescent switch of MC-GODs can serve as both a controllable drug release “guard” and “eyes” for visualized monitoring. The multi-modality therapy with controllable drug delivery, visual monitoring and high photothermal conversion efficiency may be anticipated by this versatile strategy.