Continuous 5-Hydroxymethylfurfural Production from Monosaccharides in a Microreactor
Continuous 5-Hydroxymethylfurfural Production from Monosaccharides in a Microreactor
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DOI：
10.1021/acs.iecr.7b02017
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发表时间：
2017-10-04
影响因子：
4.2
通讯作者：
Mae, Kazuhiro
中科院分区：
文献类型：
--
作者：
Muranaka, Yosuke;Nakagawa, Hiroyuki;Mae, Kazuhiro
5-在微型反应器中以单糖为原料高效合成羟甲基糠醛（HMF）。采用双相反应体系实现了所产生的HMF的立即萃取并抑制过度反应。采用微反应器确保反应在分段流下进行，以提高萃取效率。以磷酸盐缓冲液（PBS）为反应相，2-仲丁基苯酚（2BP）为萃取相，通过多次实验，确定了最佳条件。通过使用pH为2.0的PBS和与PBS的体积比为3的2BP，在180 ℃下分别将80.9摩尔%的果糖和75.7摩尔%的葡萄糖转化为HMF。通过比较通过两相反应获得的结果，证实了两相体系成功地抑制了过度反应和副产物。该体系仅使用了简单的实验装置和酸溶液及有机溶剂试剂，不需要任何复杂昂贵的催化剂。
5-Hydroxymethylfurfural (HMF) was effectively produced from monosaccharides in a microreactor. A biphasic reaction system was employed to achieve the immediate extraction of produced HMF and suppress the overreaction. A microreactor was utilized to ensure that the reaction occurred under segmented flow to enhance the extraction efficiency. Through many attempts using phosphate buffer saline (PBS) as the reaction phase and 2-sec-butyl phenol (2BP) as the extraction phase, the favorable conditions were determined. By using PBS with pH of 2.0 and 2BP at a volume ratio of 3 to PBS, 80.9 mol % of fructose and 75.7 mol % of glucose were converted into HMF, respectively, at 180 degrees C. By comparing the results obtained through monophasic reactions, it was confirmed that the biphasic system successfully suppressed both the overreaction and the byproducts. The system employed only a simple experimental apparatus and the acid solution and organic solvent reagents without any complex expensive catalyst.