Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory
Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory
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TRPV1通道对突触可塑性和空间记忆的抗应激作用
DOI：
10.1016/j.biopsych.2008.02.020
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发表时间：
2008-08-15
影响因子：
10.6
通讯作者：
Xu, Lin
中科院分区：
文献类型：
--
作者：
Li, Hong-Bin;Mao, Rong-Rong;Xu, Lin
背景：压力被认为会加重神经精神和认知障碍。特别是海马体，它在某些类型的记忆中起着关键作用，包括空间记忆，对压力非常敏感。某些类型的记忆被认为依赖于活动依赖性海马突触可塑性，如长时程增强（LTP）和长时程抑制（LTD），但应激抑制LTP，促进海马中的LTD，并损害空间记忆。虽然瞬时受体电位香草酸1（TRPV1或VR1）是广泛表达在海马中，它仍然是未知的TRPV1通道拮抗应激对海马function.Methods的影响：使用TRPV1激动剂辣椒素和resiniferatoxin和选择性拮抗剂辣椒平和S13366791，我们研究了TRPV1激活对LTP和LTD在幼年大鼠海马CA1脑片的影响。此外，我们研究是否可以防止急性应激对突触可塑性和空间记忆的影响，海马内或胃内输注的TRPV1 agonist.Results：TRPV1激动剂辣椒素和resiniferatoxin促进LTP，但抑制LTD。改变是由TRPV1介导的，因为TRPV1选择性拮抗剂辣椒平和SB366791阻断辣椒素的行动。急性应激抑制了LTP并使LTD成为可能，但TRPV1激动剂辣椒素有效地阻止了这种作用。结论：TRPV1通道是促进LTP和抑制LTD的潜在靶点，从而保护海马突触可塑性和空间记忆提取免受急性应激的影响。
Background: Stress is believed to exacerbate neuropsychiatric and cognitive disorders. In particular, the hippocampus, which plays critical roles in certain types of memory, including spatial memory, is exquisitely sensitive to stress. Certain types of memory are believed to depend on activity-dependent hippocampal synaptic plasticity such as long-term potentiation (LTP) and long-term depression (LTD), but stress suppresses LTP and facilitates LTD in the hippocampus and impairs spatial memory. Although the transient receptor potential vanilloid 1 (TRPV1 or VR1) is widely expressed in the hippocampus, it remains unknown whether the TRPV1 channel antagonizes the stress effects on hippocampal function.Methods: Using the TRPV1 agonists capsaicin and resiniferatoxin and selective antagonists capsazepine and S13366791, we examined the effect of TRPV1 activation on LTP and LTD in hippocampal CA1 slices of juvenile rats. Furthermore, we examined whether the effects of acute stress on synaptic plasticity and spatial memory could be prevented by intrahippocampal or intragastric infusion of a TRPV1 agonist.Results: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. Acute stress suppressed LTP and enabled LTD, but the TRPV1 agonist capsaicin effectively prevented this effect. When capsaicin was intrahippocampally or intragastrically infused, the acute stress effect on impairing spatial memory retrieval was completely prevented.Conclusions: The TRPV1 channel is a potential target to facilitate LTP and suppress LTD, in turn protecting hippocampal synaptic plasticity and spatial memory retrieval from the influence of acute stress.