AN ELECTRON MICROSCOPE STUDY OF DEGENERATION AND REGENERATION OF NERVE
AN ELECTRON MICROSCOPE STUDY OF DEGENERATION AND REGENERATION OF NERVE
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DOI：
10.1093/brain/85.4.799
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发表时间：
1962-01-01
期刊：
影响因子：
14.5
通讯作者：
BARTON, AA
中科院分区：
文献类型：
--
作者：
BARTON, AA
有关正常雪旺氏细胞外观的文献非常广泛，最近Causey（1960）和Robertson（1960）对此进行了综述，Robertson将注意力集中在细胞表面。正常神经中的雪旺细胞总是与神经纤维相关联。其中一部分是有髓鞘的，在Schmidt-Lantermann切口和Ranvier节点处结构特化;其他是无髓鞘的。通过光学显微镜研究，我们知道，当神经被切断时，远端会退化，而近端会产生神经纤维，这些神经纤维会长入远端残端。与此相关，许旺细胞分裂（Abercrombie和约翰逊，1946），但由于光学显微镜的分辨率相对较低，它们与这些纤维的关系尚未完全了解。本文用电镜观察了神经切断的效果，并与正常神经纤维和雪旺细胞的超微结构作了比较。
THE literature that deals with the appearance of normal Schwann cells is extensive; it has been reviewed recently by Causey (1960) and also by Robertson (1960), who confined his attention to the cell surface. Schwann cells in normal nerves are always associated with nerve fibres. A proportion of these are myelinated, with specialization of structure at the Schmidt-Lantermann incisures and nodes of Ranvier; others are nonmyelinated. It is known, as a result of light microscope studies, that when a nerve is divided the distal end degenerates while the proximal end produces nerve fibres which grow into the distal stump. In association with this the Schwann cells divide (Abercrombie and Johnson, 1946) but their relationship to these fibres is not fully understood, owing to the relatively low resolving power of the light microscope. An investigation of the effect of nerve section was made therefore with the electron microscope and the results compared with the ultrastructure of normal nerve fibres and Schwann cells.