Model validation for a noninvasive arterial stenosis detection problem.

Model validation for a noninvasive arterial stenosis detection problem.
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DOI:
10.3934/mbe.2014.11.427
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发表时间:
2014-06
期刊:
Mathematical biosciences and engineering : MBE
影响因子:
--
通讯作者:
Birch MJ
Birch MJ
中科院分区:
其他
文献类型:
--
作者:
Banks HT;Hu S;Kenz ZR;Kruse C;Shaw S;Whiteman J;Brewin MP;Greenwald SE;Birch MJ

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当前医学研究的重点是开发一种用于检测、定位和表征动脉狭窄(动脉阻塞或部分阻塞)的非侵入性方法。已经提出了一种检测胸腔中的剪切波的方法,该剪切波是由于狭窄导致的血流扰动而产生的。为了进一步发展这种方法,我们使用来自新型声学模型的一维剪切波实验数据来验证相应的粘弹性数学模型。我们估计与实验数据良好拟合(在某种意义上是精确定义的)的模型参数,并使用渐近误差理论为参数估计提供置信区间。最后,由于精确的参数估计和置信度分析需要稳健的误差模型,因此我们对测量误差的绝对模型和相对模型进行了比较。
A current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an artery). A method has been proposed to detect shear waves in the chest cavity which have been generated by disturbances in the blood flow resulting from a stenosis. In order to develop this methodology further, we use one-dimensional shear wave experimental data from novel acoustic phantoms to validate a corresponding viscoelastic mathematical model. We estimate model parameters which give a good fit (in a sense to be precisely defined) to the experimental data, and use asymptotic error theory to provide confidence intervals for parameter estimates. Finally, since a robust error model is necessary for accurate parameter estimates and confidence analysis, we include a comparison of absolute and relative models for measurement error.
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