Model validation for a noninvasive arterial stenosis detection problem.
Model validation for a noninvasive arterial stenosis detection problem.
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DOI:
10.3934/mbe.2014.11.427
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发表时间:
2014-06
期刊:
影响因子:
--
通讯作者:
Birch MJ
中科院分区:
文献类型:
--
作者:
Banks HT;Hu S;Kenz ZR;Kruse C;Shaw S;Whiteman J;Brewin MP;Greenwald SE;Birch MJ
A current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an artery). A method has been proposed to detect shear waves in the chest cavity which have been generated by disturbances in the blood flow resulting from a stenosis. In order to develop this methodology further, we use one-dimensional shear wave experimental data from novel acoustic phantoms to validate a corresponding viscoelastic mathematical model. We estimate model parameters which give a good fit (in a sense to be precisely defined) to the experimental data, and use asymptotic error theory to provide confidence intervals for parameter estimates. Finally, since a robust error model is necessary for accurate parameter estimates and confidence analysis, we include a comparison of absolute and relative models for measurement error.
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