Rooting the eukaryote tree by using a derived gene fusion
Rooting the eukaryote tree by using a derived gene fusion
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DOI：
10.1126/science.1071196
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发表时间：
2002-07-05
期刊：
影响因子：
56.9
通讯作者：
Cavalier-Smith, T
中科院分区：
文献类型：
--
作者：
Stechmann, A;Cavalier-Smith, T
由于序列进化的系统性偏差，单基因树无法定位真核生物树的根。结构遗传数据应该对深层系统发育关系产生更可靠的见解。为了找到真核生物树的根，我们搜索了主要的原生生物群体是否存在基因融合。与先前的分子研究形成鲜明对比的是，我们表明所有具有两根纤毛的真核生物群体都是进化衍生的。根位于bikonts和opisthokonts（动物，真菌，Choanozoa）之间。变形虫要么分化得更早，要么是双孔虫或（不太可能）视孔虫的姐妹。
Single-gene trees have failed to locate the root of the eukaryote tree because of systematic biases in sequence evolution. Structural genetic data should yield more reliable insights into deep phylogenetic relationships. We searched major protist groups for the presence or absence of a gene fusion in order to locate the root of the eukaryote tree. In striking contrast to previous molecular studies, we show that all eukaryote groups ancestrally with two cilia (bikonts) are evolutionarily derived. The root lies between bikonts and opisthokonts ( animals, Fungi, Choanozoa). Amoebozoa either diverged even earlier or are sister of bikonts or ( less likely) opisthokonts.