Decarboxylative Etherification of Aromatic Carboxylic Acids
Decarboxylative Etherification of Aromatic Carboxylic Acids
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DOI：
10.1021/ja304539j
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发表时间：
2012-06-20
影响因子：
15
通讯作者：
Goossen, Lukas J.
中科院分区：
文献类型：
--
作者：
Bhadra, Sukalyan;Dzik, Wojciech I.;Goossen, Lukas J.
脱羧Chan-Evans-Lam型偶联作为一种新的策略，从容易获得的芳香族羧酸开始的二芳基和烷基芳基醚的区域特异性建设。它们允许在有氧条件下，在作为脱羧催化剂的碳酸银和作为交叉偶联催化剂的乙酸铜的存在下，通过与原硅酸烷基酯或硼酸芳基酯反应，将各种芳族羧酸盐转化为相应的芳基醚。
Decarboxylative Chan-Evans-Lam-type couplings are presented as a new strategy for the regiospecific construction of diaryl and alkyl aryl ethers starting from easily available aromatic carboxylic acids. They allow converting various aromatic carboxylate salts into the corresponding aryl ethers by reaction with alkyl orthosilicates or aryl borates, under aerobic conditions in the presence of silver carbonate as the decarboxylation catalyst and copper acetate as the cross-coupling catalyst.