Convergence of EEG and fMRI measures of reward anticipation.
Convergence of EEG and fMRI measures of reward anticipation.
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DOI：
10.1016/j.biopsycho.2015.09.007
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发表时间：
2015-12
影响因子：
2.6
通讯作者：
Shankman SA
中科院分区：
文献类型：
--
作者：
Gorka SM;Phan KL;Shankman SA
奖励预期缺陷是多种精神病理学的假定机制。研究表明，这些缺陷的特点是减少左（相对于右）额叶脑电图（EEG）活动和血氧水平依赖（BOLD）的信号异常，在中脑边缘和前额叶神经区域的奖励预期。虽然人们通常认为，这两种措施捕捉类似的机制，没有研究，我们所知的直接检查额叶脑电α不对称性和功能磁共振成像（fMRI）之间的收敛在奖励预期在同一个样本。因此，本研究的目的是调查是否以及在大脑额叶脑电图α不对称性和功能磁共振成像措施相关的样本中的40名成年人。所有参与者都完成了两个类似的奖励预期任务-一个是在EEG数据收集期间，另一个是在fMRI数据收集期间。结果表明，这两个措施收敛，并在奖励预期，增加相对左额叶活动与增加左前扣带皮层（ACC）/内侧前额叶皮层（mPFC）和左眶额皮层（OFC）激活。这表明，这两种措施可能同样捕获PFC功能，这是值得注意的，因为这些区域在奖励处理和抑郁症和精神分裂症等疾病的病理生理学中的作用。
Deficits in reward anticipation are putative mechanisms for multiple psychopathologies. Research indicates that these deficits are characterized by reduced left (relative to right) frontal electroencephalogram (EEG) activity and blood oxygenation level-dependent (BOLD) signal abnormalities in mesolimbic and prefrontal neural regions during reward anticipation. Although it is often assumed that these two measures capture similar mechanisms, no study to our knowledge has directly examined the convergence between frontal EEG alpha asymmetry and functional magnetic resonance imaging (fMRI) during reward anticipation in the same sample. Therefore, the aim of the current study was to investigate if and where in the brain frontal EEG alpha asymmetry and fMRI measures were correlated in a sample of 40 adults. All participants completed two analogous reward anticipation tasks – once during EEG data collection and the other during fMRI data collection. Results indicated that the two measures do converge and that during reward anticipation, increased relative left frontal activity is associated with increased left anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC) and left orbitofrontal cortex (OFC) activation. This suggests that the two measures may similarly capture PFC functioning, which is noteworthy given the role of these regions in reward processing and the pathophysiology of disorders such as depression and schizophrenia.