Esophageal Cancer: Insights From Mouse Models.
Esophageal Cancer: Insights From Mouse Models.
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DOI：
10.4137/cgm.s21218
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Tétreault MP
中科院分区：
文献类型：
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作者：
Tétreault MP
食管癌是世界范围内第八大癌症病因和第六大癌症相关死亡原因。尽管最近在外科技术的发展与放疗和化疗的联合使用方面取得了进展，但食管癌的预后仍然很差。人们对导致食道癌发病机制的细胞和分子机制仍然知之甚少。因此，了解这些机制对于改善食道癌患者的预后至关重要。小鼠模型构成了对人类癌症建模和以在人类受试者中不可能的方式对治疗策略进行临床前测试的有价值的工具。小鼠是研究人类癌症的极好模型，因为它们在生理和分子水平上与人类相似，而且它们的妊娠时间和生命周期较短。此外，目前已经有了一系列成熟的技术，可以将基因改造引入小鼠体内。在这篇综述中，我们描述了不同的小鼠模型是如何用于研究食管癌。
Esophageal cancer is the eighth leading cause of cancer and the sixth most common cause of cancer-related death worldwide. Despite recent advances in the development of surgical techniques in combination with the use of radiotherapy and chemotherapy, the prognosis for esophageal cancer remains poor. The cellular and molecular mechanisms that drive the pathogenesis of esophageal cancer are still poorly understood. Hence, understanding these mechanisms is crucial to improving outcomes for patients with esophageal cancer. Mouse models constitute valuable tools for modeling human cancers and for the preclinical testing of therapeutic strategies in a manner not possible in human subjects. Mice are excellent models for studying human cancers because they are similar to humans at the physiological and molecular levels and because they have a shorter gestation time and life cycle. Moreover, a wide range of well-developed technologies for introducing genetic modifications into mice are currently available. In this review, we describe how different mouse models are used to study esophageal cancer.