Suppressed natural killer cell activity during episodes of erythema nodosum leprosum in lepromatous leprosy.
Suppressed natural killer cell activity during episodes of erythema nodosum leprosum in lepromatous leprosy.
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在麻风结节性红斑发作期间抑制自然杀伤细胞活性。
DOI：
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发表时间：
1982
影响因子：
4.6
通讯作者：
J. Krahenbuhl
中科院分区：
文献类型：
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作者：
R. C. Humphres;R. Gelber;J. Krahenbuhl
对麻风患者外周血单个核细胞中自然杀伤(NK)细胞活性进行了研究。交界性或麻风性麻风患者的NK活性与正常人无显著差异。然而，在一组经历了结节性麻风红斑(ENL)的麻风患者中，NK活性显著降低。在4例ENL患者中，NK活性几乎被取消。NK活性低下不能归因于皮质类固醇治疗的效果，也不是血清因素造成的。有证据表明，ENL患者的NK细胞活性低下并不是由于NK细胞本身的功能障碍；当脱离个体的单个核细胞总数时，它们的功能正常。额外的细胞耗竭研究表明，患者的单核细胞是观察到的NK活性抑制的原因。
Natural killer (NK) cell activity was investigated in peripheral blood mononuclear cells of patients with leprosy. The NK activity of patients with borderline or lepromatous leprosy did not differ significantly from that of normal subjects. However, in a group of patients with lepromatous leprosy undergoing an episode of erythema nodosum leprosum (ENL), NK activity was significantly depressed. In four patients with ENL, NK activity was virtually abolished. Depressed NK activity could not be attributed to the effects of corticosteroid therapy, nor did a serum factor appear to be responsible. Evidence was obtained that depressed NK activity in patients with ENL was not due to dysfunction of the NK cells themselves; they functioned normally when separated from the individual's total mononuclear cell population. Additional cell depletion studies suggested that the patients' monocytes were responsible for the observed depression of NK activity.